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• W2090697773 abstract "Klebsiella is suggested to trigger ankylosing spondylitis (AS) and acute anterior uveitis (AAU) in HLA-B27-positive individuals. Previous investigations showed an increased antibody response to the Klebsiella capsular types K26, K36, and K50 in sera from HLA-B27-positive AS patients. In the present study the prevalence and liters of antibodies against Klebsiella capsular antigens were measured by means of an ELISA in 32 sera from HLA-B27-positive AAU patients either with (n = 10) or without AS (n = 22) and compared with sera from HLA-B27-negative AS-patients (n = 13). Sera from either HLA-B27-positive (n = 45) or negative (n = 40) healthy individuals served as control. Sera from HLA-B27-positive AAU with or without AS showed significantly higher antibody prevalence and IgG-titers against capsular antigens of the Klebsiella serotypes K26, K36, and K50 when compared with sera from HLA-B27-negative AS patients or with healthy controls. These results might be taken to indicate the predominance of these serotypes in the HLA-B27-associated AS and AAU." @default.
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• W2090697773 date "1998-01-01" @default.
• W2090697773 modified "2023-10-12" @default.
• W2090697773 title "Humoral Immune Response to Klebsiella Capsular Polysaccharides in HLA-B27-Positive Patients with Acute Anterior Uveitis and Ankylosing Spondylitis" @default.
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• W2090697773 doi "https://doi.org/10.3109/08916939808995368" @default.
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