Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090698118> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2090698118 endingPage "544" @default.
- W2090698118 startingPage "538" @default.
- W2090698118 abstract "The 5 alpha-reductase inhibitor, 4-methyl-4-aza-3-oxo-5 alpha-pregnan-20(s)-carboxylate was utilized to examine maturational changes in testosterone synthesizing capacity of Leydig cells localizing in Band 2 and Band 3 of Percoll density gradients. Immature Band 2 Leydig cells (from 25- to 39-day-old rats) cultured without the 5 alpha-reductase inhibitor, produced increased testosterone in response to hCG or 8-br-cAMP; however, basal, hCG- or 8-br-cAMP-stimulated testosterone accumulation was 4- to 12-fold higher when cells were cultured in the presence of inhibitor. Band 2 cells from older rats produced much less testosterone in response to hCG or 8-br-cAMP (less than 3.5 pmol/10(5], even when cultured with the inhibitor. Although immature Band 3 cells cultured in the absence of 5 alpha-reductase inhibitor produced increased testosterone in response to hCG or 8-br-cAMP, testosterone levels were relatively low, because elevated 5 alpha-reductase prevented appreciable androgen accumulation; however, Band 3 cells from older rats (over 39 days old) accumulated progressively more testosterone, because of the age-dependent decline in 5 alpha-reductase activity. Immature Band 3 cells cultured with the 5 alpha-reductase inhibitor accumulated 20- to 44-fold more testosterone in response to hCG of 8-br-cAMP.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2090698118 created "2016-06-24" @default.
- W2090698118 creator A5004957488 @default.
- W2090698118 creator A5017809015 @default.
- W2090698118 date "1989-10-01" @default.
- W2090698118 modified "2023-09-25" @default.
- W2090698118 title "5α-Reductase activity regulates testosterone accumulation in two bands of immature cultured Leydig cells isolated on Percoll density gradients" @default.
- W2090698118 doi "https://doi.org/10.1530/acta.0.1210538" @default.
- W2090698118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2800927" @default.
- W2090698118 hasPublicationYear "1989" @default.
- W2090698118 type Work @default.
- W2090698118 sameAs 2090698118 @default.
- W2090698118 citedByCount "15" @default.
- W2090698118 countsByYear W20906981182018 @default.
- W2090698118 crossrefType "journal-article" @default.
- W2090698118 hasAuthorship W2090698118A5004957488 @default.
- W2090698118 hasAuthorship W2090698118A5017809015 @default.
- W2090698118 hasConcept C121608353 @default.
- W2090698118 hasConcept C126322002 @default.
- W2090698118 hasConcept C134018914 @default.
- W2090698118 hasConcept C134651460 @default.
- W2090698118 hasConcept C181199279 @default.
- W2090698118 hasConcept C185592680 @default.
- W2090698118 hasConcept C202751555 @default.
- W2090698118 hasConcept C2775874879 @default.
- W2090698118 hasConcept C2776235491 @default.
- W2090698118 hasConcept C2777736315 @default.
- W2090698118 hasConcept C2777911890 @default.
- W2090698118 hasConcept C2778575703 @default.
- W2090698118 hasConcept C2779279991 @default.
- W2090698118 hasConcept C2910366748 @default.
- W2090698118 hasConcept C48679268 @default.
- W2090698118 hasConcept C55493867 @default.
- W2090698118 hasConcept C71315377 @default.
- W2090698118 hasConcept C71924100 @default.
- W2090698118 hasConcept C86803240 @default.
- W2090698118 hasConceptScore W2090698118C121608353 @default.
- W2090698118 hasConceptScore W2090698118C126322002 @default.
- W2090698118 hasConceptScore W2090698118C134018914 @default.
- W2090698118 hasConceptScore W2090698118C134651460 @default.
- W2090698118 hasConceptScore W2090698118C181199279 @default.
- W2090698118 hasConceptScore W2090698118C185592680 @default.
- W2090698118 hasConceptScore W2090698118C202751555 @default.
- W2090698118 hasConceptScore W2090698118C2775874879 @default.
- W2090698118 hasConceptScore W2090698118C2776235491 @default.
- W2090698118 hasConceptScore W2090698118C2777736315 @default.
- W2090698118 hasConceptScore W2090698118C2777911890 @default.
- W2090698118 hasConceptScore W2090698118C2778575703 @default.
- W2090698118 hasConceptScore W2090698118C2779279991 @default.
- W2090698118 hasConceptScore W2090698118C2910366748 @default.
- W2090698118 hasConceptScore W2090698118C48679268 @default.
- W2090698118 hasConceptScore W2090698118C55493867 @default.
- W2090698118 hasConceptScore W2090698118C71315377 @default.
- W2090698118 hasConceptScore W2090698118C71924100 @default.
- W2090698118 hasConceptScore W2090698118C86803240 @default.
- W2090698118 hasIssue "4" @default.
- W2090698118 hasLocation W20906981181 @default.
- W2090698118 hasLocation W20906981182 @default.
- W2090698118 hasOpenAccess W2090698118 @default.
- W2090698118 hasPrimaryLocation W20906981181 @default.
- W2090698118 hasRelatedWork W1976688049 @default.
- W2090698118 hasRelatedWork W1979452793 @default.
- W2090698118 hasRelatedWork W2011059160 @default.
- W2090698118 hasRelatedWork W2014027373 @default.
- W2090698118 hasRelatedWork W2040706140 @default.
- W2090698118 hasRelatedWork W2045185957 @default.
- W2090698118 hasRelatedWork W2089929552 @default.
- W2090698118 hasRelatedWork W2102225311 @default.
- W2090698118 hasRelatedWork W2121739803 @default.
- W2090698118 hasRelatedWork W2150227685 @default.
- W2090698118 hasVolume "121" @default.
- W2090698118 isParatext "false" @default.
- W2090698118 isRetracted "false" @default.
- W2090698118 magId "2090698118" @default.
- W2090698118 workType "article" @default.