FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090699441> ?p ?o ?g. }

• W2090699441 endingPage "1504" @default.
• W2090699441 startingPage "1487" @default.
• W2090699441 abstract "Structural genomics projects are producing many three-dimensional structures of proteins that have been identified only from their gene sequences. It is therefore important to develop computational methods that will predict sites involved in productive intermolecular interactions that might give clues about functions. Techniques based on evolutionary conservation of amino acids have the advantage over physiochemical methods in that they are more general. However, the majority of techniques neither use all available structural and sequence information, nor are able to distinguish between evolutionary restraints that arise from the need to maintain structure and those that arise from function. Three methods to identify evolutionary restraints on protein sequence and structure are described here. The first identifies those residues that have a higher degree of conservation than expected: this is achieved by comparing for each amino acid position the sequence conservation observed in the homologous family of proteins with the degree of conservation predicted on the basis of amino acid type and local environment. The second uses information theory to identify those positions where environment-specific substitution tables make poor predictions of the overall amino acid substitution pattern. The third method identifies those residues that have highly conserved positions when three-dimensional structures of proteins in a homologous family are superposed. The scores derived from these methods are mapped onto the protein three-dimensional structures and contoured, allowing identification clusters of residues with strong evolutionary restraints that are sites of interaction in proteins involved in a variety of functions. Our method differs from other published techniques by making use of structural information to identify restraints that arise from the structure of the protein and differentiating these restraints from others that derive from intermolecular interactions that mediate functions in the whole organism." @default.
• W2090699441 created "2016-06-24" @default.
• W2090699441 creator A5000605194 @default.
• W2090699441 creator A5001029093 @default.
• W2090699441 creator A5041054741 @default.
• W2090699441 creator A5048740840 @default.
• W2090699441 date "2004-10-01" @default.
• W2090699441 modified "2023-10-16" @default.
• W2090699441 title "Distinguishing Structural and Functional Restraints in Evolution in Order to Identify Interaction Sites" @default.
• W2090699441 cites W1508885706 @default.
• W2090699441 cites W1513073936 @default.
• W2090699441 cites W1593454066 @default.
• W2090699441 cites W1966679395 @default.
• W2090699441 cites W1968733906 @default.
• W2090699441 cites W1974480392 @default.
• W2090699441 cites W1975563330 @default.
• W2090699441 cites W1975796937 @default.
• W2090699441 cites W1977949195 @default.
• W2090699441 cites W1978041454 @default.
• W2090699441 cites W1987328021 @default.
• W2090699441 cites W1991570251 @default.
• W2090699441 cites W2000584915 @default.
• W2090699441 cites W2001964005 @default.
• W2090699441 cites W2002478143 @default.
• W2090699441 cites W2003066987 @default.
• W2090699441 cites W2003788979 @default.
• W2090699441 cites W2004178884 @default.
• W2090699441 cites W2010979459 @default.
• W2090699441 cites W2016753466 @default.
• W2090699441 cites W2020481171 @default.
• W2090699441 cites W2021534482 @default.
• W2090699441 cites W2026185422 @default.
• W2090699441 cites W2027036222 @default.
• W2090699441 cites W2035436553 @default.
• W2090699441 cites W2036792999 @default.
• W2090699441 cites W2037817043 @default.
• W2090699441 cites W2038936167 @default.
• W2090699441 cites W2052262181 @default.
• W2090699441 cites W2059067075 @default.
• W2090699441 cites W2062880866 @default.
• W2090699441 cites W2065385636 @default.
• W2090699441 cites W2077494556 @default.
• W2090699441 cites W2086719212 @default.
• W2090699441 cites W2094148990 @default.
• W2090699441 cites W2099075703 @default.
• W2090699441 cites W2111909811 @default.
• W2090699441 cites W2115230913 @default.
• W2090699441 cites W2115339329 @default.
• W2090699441 cites W2119498937 @default.
• W2090699441 cites W2120564439 @default.
• W2090699441 cites W2122701269 @default.
• W2090699441 cites W2123105772 @default.
• W2090699441 cites W2128827201 @default.
• W2090699441 cites W2130479394 @default.
• W2090699441 cites W2132094529 @default.
• W2090699441 cites W2132844390 @default.
• W2090699441 cites W2137991504 @default.
• W2090699441 cites W2141885858 @default.
• W2090699441 cites W2142757818 @default.
• W2090699441 cites W2143173841 @default.
• W2090699441 cites W2144333666 @default.
• W2090699441 cites W2146950091 @default.
• W2090699441 cites W2149026172 @default.
• W2090699441 cites W2155367844 @default.
• W2090699441 cites W2156728093 @default.
• W2090699441 cites W2158714788 @default.
• W2090699441 cites W2163352757 @default.
• W2090699441 cites W2165181282 @default.
• W2090699441 cites W2166745327 @default.
• W2090699441 cites W2169890434 @default.
• W2090699441 cites W2171653972 @default.
• W2090699441 cites W2916193864 @default.
• W2090699441 cites W4210531204 @default.
• W2090699441 cites W4327849160 @default.
• W2090699441 doi "https://doi.org/10.1016/j.jmb.2004.08.022" @default.
• W2090699441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15364576" @default.
• W2090699441 hasPublicationYear "2004" @default.
• W2090699441 type Work @default.
• W2090699441 sameAs 2090699441 @default.
• W2090699441 citedByCount "91" @default.
• W2090699441 countsByYear W20906994412012 @default.
• W2090699441 countsByYear W20906994412013 @default.
• W2090699441 countsByYear W20906994412014 @default.
• W2090699441 countsByYear W20906994412015 @default.
• W2090699441 countsByYear W20906994412016 @default.
• W2090699441 countsByYear W20906994412017 @default.
• W2090699441 countsByYear W20906994412018 @default.
• W2090699441 countsByYear W20906994412019 @default.
• W2090699441 countsByYear W20906994412020 @default.
• W2090699441 countsByYear W20906994412021 @default.
• W2090699441 countsByYear W20906994412022 @default.
• W2090699441 countsByYear W20906994412023 @default.
• W2090699441 crossrefType "journal-article" @default.
• W2090699441 hasAuthorship W2090699441A5000605194 @default.
• W2090699441 hasAuthorship W2090699441A5001029093 @default.
• W2090699441 hasAuthorship W2090699441A5041054741 @default.
• W2090699441 hasAuthorship W2090699441A5048740840 @default.
• W2090699441 hasConcept C10138342 @default.

• next