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- W2090715342 abstract "The underlying cellular mechanisms that characterize aging are complex and multifaceted. However, it is emerging that aging could be regulated by two distinct metabolic hubs. These hubs are the pathway defined by the mammalian target of rapamycin (mTOR) and that defined by the NAD+-dependent deacetylase enzyme, SIRT1. Recent experimental evidence suggests that there is crosstalk between these two important pathways; however, the mechanisms underpinning their interaction(s) remains poorly understood. In this review, we propose using computational modelling in tandem with experimentation to delineate the mechanism(s). We briefly discuss the main modelling frameworks that could be used to disentangle this relationship and present a reduced reaction pathway that could be modelled. We conclude by outlining the limitations of computational modelling and by discussing opportunities for future progress in this area." @default.
- W2090715342 created "2016-06-24" @default.
- W2090715342 creator A5004477353 @default.
- W2090715342 creator A5025311566 @default.
- W2090715342 creator A5067185278 @default.
- W2090715342 creator A5088541931 @default.
- W2090715342 date "2015-04-27" @default.
- W2090715342 modified "2023-10-16" @default.
- W2090715342 title "Mathematical Modelling of Metabolic Regulation in Aging" @default.
- W2090715342 cites W1497372913 @default.
- W2090715342 cites W1523693806 @default.
- W2090715342 cites W1527713674 @default.
- W2090715342 cites W1572421661 @default.
- W2090715342 cites W1586159393 @default.
- W2090715342 cites W1589421810 @default.
- W2090715342 cites W1658682427 @default.
- W2090715342 cites W1964301516 @default.
- W2090715342 cites W1966082815 @default.
- W2090715342 cites W1966411345 @default.
- W2090715342 cites W1967899825 @default.
- W2090715342 cites W1968065063 @default.
- W2090715342 cites W1971585815 @default.
- W2090715342 cites W1977534471 @default.
- W2090715342 cites W1978229561 @default.
- W2090715342 cites W1979657807 @default.
- W2090715342 cites W1983673827 @default.
- W2090715342 cites W1988338260 @default.
- W2090715342 cites W1989263028 @default.
- W2090715342 cites W1990354752 @default.
- W2090715342 cites W2002635898 @default.
- W2090715342 cites W2004314923 @default.
- W2090715342 cites W2008769660 @default.
- W2090715342 cites W2009128541 @default.
- W2090715342 cites W2010583480 @default.
- W2090715342 cites W2012099961 @default.
- W2090715342 cites W2013287222 @default.
- W2090715342 cites W2014087704 @default.
- W2090715342 cites W2015173256 @default.
- W2090715342 cites W2015361145 @default.
- W2090715342 cites W2017605860 @default.
- W2090715342 cites W2020518388 @default.
- W2090715342 cites W2020559696 @default.
- W2090715342 cites W2022984399 @default.
- W2090715342 cites W2025133084 @default.
- W2090715342 cites W2026089579 @default.
- W2090715342 cites W2026351725 @default.
- W2090715342 cites W2028178274 @default.
- W2090715342 cites W2029070451 @default.
- W2090715342 cites W2032983681 @default.
- W2090715342 cites W2034451927 @default.
- W2090715342 cites W2035029345 @default.
- W2090715342 cites W2036145275 @default.
- W2090715342 cites W2036755369 @default.
- W2090715342 cites W2037653131 @default.
- W2090715342 cites W2038881106 @default.
- W2090715342 cites W2039301709 @default.
- W2090715342 cites W2039806098 @default.
- W2090715342 cites W2041198010 @default.
- W2090715342 cites W2042200655 @default.
- W2090715342 cites W2042321087 @default.
- W2090715342 cites W2048376025 @default.
- W2090715342 cites W2049599293 @default.
- W2090715342 cites W2050980183 @default.
- W2090715342 cites W2057113393 @default.
- W2090715342 cites W2059278059 @default.
- W2090715342 cites W2061180659 @default.
- W2090715342 cites W2065952016 @default.
- W2090715342 cites W2066416578 @default.
- W2090715342 cites W2067443877 @default.
- W2090715342 cites W2068337326 @default.
- W2090715342 cites W2069157810 @default.
- W2090715342 cites W2069546570 @default.
- W2090715342 cites W2071673220 @default.
- W2090715342 cites W2073701988 @default.
- W2090715342 cites W2074560224 @default.
- W2090715342 cites W2075614768 @default.
- W2090715342 cites W2076153333 @default.
- W2090715342 cites W2077612844 @default.
- W2090715342 cites W2078355959 @default.
- W2090715342 cites W2078734278 @default.
- W2090715342 cites W2081382143 @default.
- W2090715342 cites W2082948758 @default.
- W2090715342 cites W2084191360 @default.
- W2090715342 cites W2084924279 @default.
- W2090715342 cites W2089564505 @default.
- W2090715342 cites W2091198609 @default.
- W2090715342 cites W2092543853 @default.
- W2090715342 cites W2093470850 @default.
- W2090715342 cites W2097368536 @default.
- W2090715342 cites W2098016440 @default.
- W2090715342 cites W2100525485 @default.
- W2090715342 cites W2101155309 @default.
- W2090715342 cites W2101861123 @default.
- W2090715342 cites W2102653059 @default.
- W2090715342 cites W2102799140 @default.
- W2090715342 cites W2107047038 @default.
- W2090715342 cites W2107333582 @default.
- W2090715342 cites W2108723074 @default.