Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090717291> ?p ?o ?g. }
- W2090717291 endingPage "204" @default.
- W2090717291 startingPage "194" @default.
- W2090717291 abstract "Current levels of occupational exposure to benzene, a genotoxic human carcinogen, in Western countries are reduced by two–three orders of magnitude (from ppm to ppb) as compared to the past. However, as benzene toxicity is strongly dependent on biotransformation and recent evidence underlines a higher efficiency of bio-activation pathways at lower levels of exposure, toxic effects at low doses could be higher than expected, particularly in susceptible individuals. Currently, biological monitoring can allow accurate exposure assessment, relying on sensitive and specific enough biomarkers of internal dose. The availability of similarly reliable biomarkers of early effect or susceptibility could greatly improve the risk assessment process to such an extent that risk could even be assessed at the individual level. As to susceptibility biomarkers, functional genetic polymorphisms of relevant biotransformation enzymes may modulate the risk of adverse effects (NQO1) and the levels of biomarkers of internal dose, in particular S-phenylmercapturic acid (GSTM1, GSTT1, GSTA1). Among biomarkers of early effect, genotoxicity indicators, although sensitive in some cases, are too aspecific for routine use in occupational health surveillance programmes. Currently only the periodical blood cell count seems suitable enough to be applied in the longitudinal monitoring of effects from benzene exposure. Novel biomarkers of early effect are expected from higher collaboration among toxicologists and clinicians, also using advanced “omics” techniques." @default.
- W2090717291 created "2016-06-24" @default.
- W2090717291 creator A5004356655 @default.
- W2090717291 creator A5057165095 @default.
- W2090717291 date "2014-12-01" @default.
- W2090717291 modified "2023-09-25" @default.
- W2090717291 title "Metabolic polymorphisms and biomarkers of effect in the biomonitoring of occupational exposure to low-levels of benzene: State of the art" @default.
- W2090717291 cites W1661463402 @default.
- W2090717291 cites W1914476337 @default.
- W2090717291 cites W1965437953 @default.
- W2090717291 cites W1968190361 @default.
- W2090717291 cites W1969428572 @default.
- W2090717291 cites W1971662834 @default.
- W2090717291 cites W1974190468 @default.
- W2090717291 cites W1974560609 @default.
- W2090717291 cites W1974870303 @default.
- W2090717291 cites W1975667758 @default.
- W2090717291 cites W1976306324 @default.
- W2090717291 cites W1977579563 @default.
- W2090717291 cites W1978429992 @default.
- W2090717291 cites W1980644479 @default.
- W2090717291 cites W1983618477 @default.
- W2090717291 cites W1984135844 @default.
- W2090717291 cites W1985206870 @default.
- W2090717291 cites W1986343673 @default.
- W2090717291 cites W1987741085 @default.
- W2090717291 cites W1989843733 @default.
- W2090717291 cites W1990763586 @default.
- W2090717291 cites W1991233596 @default.
- W2090717291 cites W1992574560 @default.
- W2090717291 cites W1993167696 @default.
- W2090717291 cites W1995966979 @default.
- W2090717291 cites W1999112627 @default.
- W2090717291 cites W2001473103 @default.
- W2090717291 cites W2002420533 @default.
- W2090717291 cites W2003093710 @default.
- W2090717291 cites W2006338813 @default.
- W2090717291 cites W2006844469 @default.
- W2090717291 cites W2011579785 @default.
- W2090717291 cites W2013994456 @default.
- W2090717291 cites W2014372601 @default.
- W2090717291 cites W2015294482 @default.
- W2090717291 cites W2016029453 @default.
- W2090717291 cites W2017658807 @default.
- W2090717291 cites W2020204908 @default.
- W2090717291 cites W2021092719 @default.
- W2090717291 cites W2022582116 @default.
- W2090717291 cites W2024380355 @default.
- W2090717291 cites W2024570952 @default.
- W2090717291 cites W2026260148 @default.
- W2090717291 cites W2028361287 @default.
- W2090717291 cites W2029978452 @default.
- W2090717291 cites W2030592455 @default.
- W2090717291 cites W2031967567 @default.
- W2090717291 cites W2032694449 @default.
- W2090717291 cites W2034379110 @default.
- W2090717291 cites W2036407540 @default.
- W2090717291 cites W2036409146 @default.
- W2090717291 cites W2036818818 @default.
- W2090717291 cites W2038288403 @default.
- W2090717291 cites W2042468644 @default.
- W2090717291 cites W2046579535 @default.
- W2090717291 cites W2047028713 @default.
- W2090717291 cites W2053621737 @default.
- W2090717291 cites W2054278406 @default.
- W2090717291 cites W2054984477 @default.
- W2090717291 cites W2055196056 @default.
- W2090717291 cites W2056182559 @default.
- W2090717291 cites W2057281286 @default.
- W2090717291 cites W2058383716 @default.
- W2090717291 cites W2060185272 @default.
- W2090717291 cites W2060937780 @default.
- W2090717291 cites W2063137707 @default.
- W2090717291 cites W2067131495 @default.
- W2090717291 cites W2068842871 @default.
- W2090717291 cites W2071122712 @default.
- W2090717291 cites W2071156112 @default.
- W2090717291 cites W2072249097 @default.
- W2090717291 cites W2075174342 @default.
- W2090717291 cites W2077959186 @default.
- W2090717291 cites W2078753358 @default.
- W2090717291 cites W2079643463 @default.
- W2090717291 cites W2079984654 @default.
- W2090717291 cites W2081529380 @default.
- W2090717291 cites W2084698235 @default.
- W2090717291 cites W2087542439 @default.
- W2090717291 cites W2088255283 @default.
- W2090717291 cites W2088708799 @default.
- W2090717291 cites W2088840007 @default.
- W2090717291 cites W2091456496 @default.
- W2090717291 cites W2092996697 @default.
- W2090717291 cites W2093294355 @default.
- W2090717291 cites W2093384103 @default.
- W2090717291 cites W2093520294 @default.
- W2090717291 cites W2096830976 @default.
- W2090717291 cites W2106625186 @default.
- W2090717291 cites W2107146234 @default.
- W2090717291 cites W2107278493 @default.