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- W2090728209 abstract "Because of several reports suggesting a possible immunologic basis for heroin lung, we evaluated the sera of 64 consecutively hospitalized patients with a history of heroin use for levels of the five classes of immunoglobulins (IgM, IgG, IgA, IgD, and IgE), complement component C3, and total serum complement. Although elevated in 81 percent (52) of 64 addicts tested, the IgM level was found to be significantly decreased in the 22 addicts with pulmonary edema as compared to the 42 without heroin lung. Additionally, both C3 and total serum complement values were significantly lower in the addicts with pulmonary edema. Though an adequate explanation for the differences between these two groups of addicts is not readily apparent, we suggest that IgM and complement may play an active role in heroin-induced pulmonary edema. Because of several reports suggesting a possible immunologic basis for heroin lung, we evaluated the sera of 64 consecutively hospitalized patients with a history of heroin use for levels of the five classes of immunoglobulins (IgM, IgG, IgA, IgD, and IgE), complement component C3, and total serum complement. Although elevated in 81 percent (52) of 64 addicts tested, the IgM level was found to be significantly decreased in the 22 addicts with pulmonary edema as compared to the 42 without heroin lung. Additionally, both C3 and total serum complement values were significantly lower in the addicts with pulmonary edema. Though an adequate explanation for the differences between these two groups of addicts is not readily apparent, we suggest that IgM and complement may play an active role in heroin-induced pulmonary edema." @default.
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- W2090728209 date "1975-11-01" @default.
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- W2090728209 title "Immunologic Abnormalities in Heroin Lung" @default.
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- W2090728209 doi "https://doi.org/10.1378/chest.68.5.651" @default.
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