Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090732394> ?p ?o ?g. }
- W2090732394 endingPage "493" @default.
- W2090732394 startingPage "477" @default.
- W2090732394 abstract "Eye induction and eye field separation are the earliest events during vertebrate eye development. Both of these processes occur much earlier than the formation of optic vesicles. The insulin-like growth factor (IGF) pathway appears to be essential for eye induction, yet it remains unclear how IGF downstream pathways are involved in eye induction. As a consequence of eye induction, a single eye anlage is specified in the anterior neural plate. Subsequently, this single eye anlage is divided into two symmetric eye fields in response to Sonic Hedgehog (Shh) secreted from the prechordal mesoderm. Here, we report that B56epsilon regulatory subunit of protein phosphatase 2A (PP2A) is involved in Xenopus eye induction and subsequent eye field separation. We provide evidence that B56epsilon is required for the IGF/PI3K/Akt pathway and that interfering with the PI3K/Akt pathway inhibits eye induction. In addition, we show that B56epsilon regulates the Hedgehog (Hh) pathway during eye field separation. Thus, B56epsilon is involved in multiple signaling pathways and plays critical roles during early development." @default.
- W2090732394 created "2016-06-24" @default.
- W2090732394 creator A5015129046 @default.
- W2090732394 creator A5028542935 @default.
- W2090732394 creator A5030694429 @default.
- W2090732394 creator A5034386063 @default.
- W2090732394 creator A5036910844 @default.
- W2090732394 creator A5041383601 @default.
- W2090732394 date "2007-02-01" @default.
- W2090732394 modified "2023-09-30" @default.
- W2090732394 title "PP2A:B56ε is required for eye induction and eye field separation" @default.
- W2090732394 cites W1541949755 @default.
- W2090732394 cites W1564357553 @default.
- W2090732394 cites W1589588578 @default.
- W2090732394 cites W1751159137 @default.
- W2090732394 cites W1811130017 @default.
- W2090732394 cites W1867818836 @default.
- W2090732394 cites W1887965115 @default.
- W2090732394 cites W1895875855 @default.
- W2090732394 cites W1902497723 @default.
- W2090732394 cites W1944789371 @default.
- W2090732394 cites W1964739066 @default.
- W2090732394 cites W1965671498 @default.
- W2090732394 cites W1965772224 @default.
- W2090732394 cites W1966435498 @default.
- W2090732394 cites W1967886525 @default.
- W2090732394 cites W1968926070 @default.
- W2090732394 cites W1972666776 @default.
- W2090732394 cites W1974670329 @default.
- W2090732394 cites W1981034693 @default.
- W2090732394 cites W1985477248 @default.
- W2090732394 cites W1988233502 @default.
- W2090732394 cites W1989959348 @default.
- W2090732394 cites W1989985789 @default.
- W2090732394 cites W1989991277 @default.
- W2090732394 cites W1992342289 @default.
- W2090732394 cites W1997862931 @default.
- W2090732394 cites W1998776582 @default.
- W2090732394 cites W1999762161 @default.
- W2090732394 cites W2001350050 @default.
- W2090732394 cites W2005943162 @default.
- W2090732394 cites W2007411336 @default.
- W2090732394 cites W2007817359 @default.
- W2090732394 cites W2011409454 @default.
- W2090732394 cites W2013541197 @default.
- W2090732394 cites W2014460650 @default.
- W2090732394 cites W2017894144 @default.
- W2090732394 cites W2018142096 @default.
- W2090732394 cites W2019625059 @default.
- W2090732394 cites W2023497062 @default.
- W2090732394 cites W2025567758 @default.
- W2090732394 cites W2031789904 @default.
- W2090732394 cites W2031984950 @default.
- W2090732394 cites W2034621490 @default.
- W2090732394 cites W2041170795 @default.
- W2090732394 cites W2041468806 @default.
- W2090732394 cites W2045947221 @default.
- W2090732394 cites W2046256742 @default.
- W2090732394 cites W2050556924 @default.
- W2090732394 cites W2053351302 @default.
- W2090732394 cites W2058576991 @default.
- W2090732394 cites W2059614045 @default.
- W2090732394 cites W2062259699 @default.
- W2090732394 cites W2065231473 @default.
- W2090732394 cites W2066893159 @default.
- W2090732394 cites W2071135527 @default.
- W2090732394 cites W2071507443 @default.
- W2090732394 cites W2081939122 @default.
- W2090732394 cites W2083959249 @default.
- W2090732394 cites W2085590667 @default.
- W2090732394 cites W2085690923 @default.
- W2090732394 cites W2089749296 @default.
- W2090732394 cites W2090922624 @default.
- W2090732394 cites W2091637225 @default.
- W2090732394 cites W2093625343 @default.
- W2090732394 cites W2094809543 @default.
- W2090732394 cites W2097923096 @default.
- W2090732394 cites W2099118069 @default.
- W2090732394 cites W2101803513 @default.
- W2090732394 cites W2102345821 @default.
- W2090732394 cites W2104406613 @default.
- W2090732394 cites W2108707301 @default.
- W2090732394 cites W2108909298 @default.
- W2090732394 cites W2112609051 @default.
- W2090732394 cites W2112718652 @default.
- W2090732394 cites W2115686163 @default.
- W2090732394 cites W2115925427 @default.
- W2090732394 cites W2122565002 @default.
- W2090732394 cites W2125068279 @default.
- W2090732394 cites W2125499046 @default.
- W2090732394 cites W2126245868 @default.
- W2090732394 cites W2127312018 @default.
- W2090732394 cites W2128849220 @default.
- W2090732394 cites W2131716017 @default.
- W2090732394 cites W2132549779 @default.
- W2090732394 cites W2133650476 @default.
- W2090732394 cites W2138007884 @default.
- W2090732394 cites W2141694824 @default.