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- W2090740137 abstract "Bruno Garcia and colleagues (March 3, p 690)1Garcia B Ramaholimihaso F Diebold M-D Cadiot G Thiefin G Ischaemic colitis in a patients taking meloxicam.Lancet. 2001; 357: 690Summary Full Text Full Text PDF PubMed Scopus (22) Google Scholar describe a patient with ischaemic colitis, who had been taking meloxicam. They mention high doses of meloxicam as the cause of the ischaemic colitis. I believe, however, that this case shows only a possible association between this drug and colon ischaemia. It is now well known that most cases of colon ischaemia occur because of localised low flow and are non-occlusive in nature, but are perhaps related to small vessel disease. Although a long list of factors, including multiple drugs, are associated with ischaemic colitis, most cases are spontaneous and arise in the absence of a proven precipitating event.2Brandt LJ Smithline AE Ischemic lesions of the bowel.in: Feldman M Scharschmidt BF Sleisenger MH Sleisenger and Fordtran's gastrointestinal and liver disease: pathophysiology, diagnosis and management. 6th edn. WB Saunders, Philadelphia1998: 2017-2019Google Scholar, 3Boley SJ Colon ischemia: 25 years later.Am J Gastroenterol. 1990; 8: 931-935Google Scholar Furthermore, although the spectrum of clinical presentations is broad, most episodes ordinarily resolve rapidly and respond to general supportive measures, as in the case described by Garcia and colleagues. Their case involved the splenic flexure, and descending and sigmoid colon regions, which are frequently involved in the most common form of ischaemic colitis. Lastly, as I believe Garcia and colleagues correctly concluded, the case under discussion did not present clinically or endoscopically as would a case of colon damage or ulceration induced by non-steroidal anti-inflammatory drugs, an entity of which gastroenterologists are becoming more aware.4Kurahara K Matsumoto T Iida M Honda K Yao T Fujishima M Clinical and endoscopic features of nonsteroidal anti-inflammatory drug-induced colon ulcerations.Am J Gastroenterol. 2001; 36: 473-480Crossref Google Scholar The temporal association of drug administration, lack of other possible causes, and resolution of symptoms after drug withdrawal, are sufficient to unequivocally prove causation. As such, at this juncture, it is not appropriate to suggest that meloxicam is a clear cause of ischaemic colitis." @default.
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- W2090740137 date "2001-05-01" @default.
- W2090740137 modified "2023-09-24" @default.
- W2090740137 title "Ischaemic colitis and meloxicam" @default.
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- W2090740137 doi "https://doi.org/10.1016/s0140-6736(00)04756-5" @default.
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