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• W2090745296 abstract "Direct measurement of intra-arterial blood pressure (BP) for 24-h provides approximately 100,000 values that vary enormously, but each (BPi) can be expressed by the equation BPi=BP0+ΔBPi (BP0, base BP; ΔBPi, BP increment, i=1, 2, …, 100×103). About 20% of outpatients with hypertension exhibit white-coat hypertension (WCH). In such patients, ΔBPc (i=c; c, time at the clinic) is surmised to be large. A method for explaining the physiological factors in ΔBPc and the estimation of base BP in the outpatient clinic is important. This study addresses this issue. A total of 293 subjects were divided into four groups: 1) WCH group, 45 individuals (office BP ≥140/90 mmHg and 24-h indirect BP <125/80 mmHg); 2) normotensive (NT) group, 84 controls matched for age and sex; 3) WHO-I group, 95 hypertensive patients with WHO stage I (office BP ≥140/90 mmHg and 24-h BP ≥125/80 mmHg); and 4) WHO-II group, 69 hypertensive patients with WHO stage II. Their BPc and heart rate (HR; HRc, clinic HR) values were measured by a BP-ECG monitoring device in the outpatient clinic. Power-spectral analysis was used to obtain the ratio between the low-frequency component (LF) and high-frequency component (HF) of ECG-RR variability (LF/HF=LH). Twenty-four-hour indirect BP (and BP0) and base HR (HR0) were measured by a portable device (TM2425) at 30-min intervals. Then, ΔBPc (=BPc−BP0) was estimated by performing linear multivariate analysis applying the model equation ΔBPc=(BPc−αLH)(1−βHR0/HRc)+ε to the above variables (α and β, constant values; ε, error). This model equation made it possible to estimate BP0 (and ΔBPc) with a high coefficient of correlation (r ≥0.85, mean of error less than 0.82±5.9 mmHg). The predictive accuracy for discrimination between WCH and sustained hypertension (WHO-I and WHO-II groups) by this equation was 88%. The new ΔBP-estimation device (BP-ECG monitor) enabled us to infer BP0 and is therefore useful in estimating WCH in the outpatient clinic." @default.
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• W2090745296 date "2006-01-01" @default.
• W2090745296 modified "2023-10-10" @default.
• W2090745296 title "Estimation of Base Blood Pressure by Using a New Device in the Outpatient Clinic" @default.
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• W2090745296 doi "https://doi.org/10.1291/hypres.29.233" @default.
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