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- W2090745860 endingPage "412" @default.
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- W2090745860 abstract "Topoisomerase I (Topo-I) is a major target for anticancer drug discovery and design. As a result, Topo-I inhibitors constitute an important class of the current anticancer drugs. To date, all of the Topo-I inhibitors that have been clinically evaluated are analogues of camptothecin (CPT), an extract of the Chinese tree Camptotheca acuminata. CPT has shown significant antitumor activity to lung, ovarian, breast, pancreas and stomach cancers. In this article the, phytochemical aspect, and various structural modifications are comprehensively reviewed as in rings A, B, C, D and E. Biological activity of camptothecin, other than anticancer, reported till the year 2003 has also been discussed." @default.
- W2090745860 created "2016-06-24" @default.
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- W2090745860 creator A5076172540 @default.
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- W2090745860 date "2005-06-01" @default.
- W2090745860 modified "2023-10-14" @default.
- W2090745860 title "Camptothecin and its analogues: a review on their chemotherapeutic potential" @default.
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- W2090745860 doi "https://doi.org/10.1080/14786410412331299005" @default.
- W2090745860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15938148" @default.
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