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• W2090750277 abstract "A novel series of small molecule C5a antagonists is reported. In particular, in vitro metabolic studies and solution based combinatorial synthesis are demonstrated as useful tools for the rapid identification of antagonists with low in vitro clearance. Members of this series specifically inhibited the binding of 125I-labeled C5a to human recombinant C5a receptor (C5aR). In functional cell assays these compounds displayed surmountable antagonism against C5a and did not demonstrate any detectable agonist activity." @default.
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• W2090750277 date "2009-02-01" @default.
• W2090750277 modified "2023-10-01" @default.
• W2090750277 title "Discovery of small molecule human C5a receptor antagonists" @default.
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• W2090750277 doi "https://doi.org/10.1016/j.bmcl.2008.12.104" @default.
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