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• W2090751364 abstract "The stimulatory effect of forskolin on amylase secretion was studied by pretreating rat parotid tissue with forskolin for 10 min. incubating it in medijm without forskolin for 10 min. and then treating it with forskolin again. Pretreatmant with 10//M forskolin for 10 min resulted in increased amylase secretion and enhanced accumulation of cyclic AMP in the tissue during the second incubation with forskolin. In the presence of colchicine or vinblastine, the enhancement in cyclic AMP accumulation during the second incubation with forskolin was prevented. but the increased amylase secretion remained unchanged. The increased amylase secretion was counteracted only in the presence of concanavalin A. On the other hand, increased amylase secretion induced by isoproterenol (IPR) pretreatment was counteracted by colchicine, vinblastine, concanavalin A or strychnine. These data suggest that the total amount of cyclic AMP in the tissue does not have any essential role in the supersensitivity of the amylase secretory response, and that the supersensitivity induced by forskolin differs from that induced by IPR." @default.
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• W2090751364 date "1985-01-01" @default.
• W2090751364 modified "2023-09-23" @default.
• W2090751364 title "Forskolin Induces Supersensitivity of the Amylase Secretory Response of Rat Parotid Tissue" @default.
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• W2090751364 doi "https://doi.org/10.1254/jjp.39.39" @default.
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