FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090758857> ?p ?o ?g. }

• W2090758857 endingPage "14651" @default.
• W2090758857 startingPage "14644" @default.
• W2090758857 abstract "Stem cells, believed to be the cellular origin of glioma, are able to generate gliomas, according to experimental studies. Here we investigated the potential and circumstances of more differentiated cells to generate glioma development. We and others have shown that oligodendrocyte precursor cells (OPCs) can also be the cell of origin for experimental oligodendroglial tumors. However, the question of whether OPCs have the capacity to initiate astrocytic gliomas remains unanswered. Astrocytic and oligodendroglial tumors represent the two most common groups of glioma and have been considered as distinct disease groups with putatively different origins. Here we show that mouse OPCs can give rise to both types of glioma given the right circumstances. We analyzed tumors induced by K-RAS and AKT and compared them to oligodendroglial platelet-derived growth factor B-induced tumors in Ctv-a mice with targeted deletions of Cdkn2a (p16 Ink4a−/− , p19 Arf−/− , Cdkn2a −/− ). Our results showed that glioma can originate from OPCs through overexpression of K-RAS and AKT when combined with p19 Arf loss, and these tumors displayed an astrocytic histology and high expression of astrocytic markers. We argue that OPCs have the potential to develop both astrocytic and oligodendroglial tumors given loss of p19 Arf , and that oncogenic signaling is dominant to cell of origin in determining glioma phenotype. Our mouse data are supported by the fact that human astrocytoma and oligodendroglioma display a high degree of overlap in global gene expression with no clear distinctions between the two diagnoses." @default.
• W2090758857 created "2016-06-24" @default.
• W2090758857 creator A5000874395 @default.
• W2090758857 creator A5011954889 @default.
• W2090758857 creator A5021838367 @default.
• W2090758857 creator A5031828954 @default.
• W2090758857 creator A5047714102 @default.
• W2090758857 creator A5049016199 @default.
• W2090758857 creator A5066165135 @default.
• W2090758857 creator A5076104674 @default.
• W2090758857 date "2014-10-29" @default.
• W2090758857 modified "2023-10-14" @default.
• W2090758857 title "Oncogenic Signaling Is Dominant to Cell of Origin and Dictates Astrocytic or Oligodendroglial Tumor Development from Oligodendrocyte Precursor Cells" @default.
• W2090758857 cites W1893588436 @default.
• W2090758857 cites W1894124425 @default.
• W2090758857 cites W1973886069 @default.
• W2090758857 cites W1982479809 @default.
• W2090758857 cites W1983077588 @default.
• W2090758857 cites W1993252508 @default.
• W2090758857 cites W2009149174 @default.
• W2090758857 cites W2010677999 @default.
• W2090758857 cites W2014331589 @default.
• W2090758857 cites W2017235640 @default.
• W2090758857 cites W2030083720 @default.
• W2090758857 cites W2035207421 @default.
• W2090758857 cites W2036580114 @default.
• W2090758857 cites W2042571037 @default.
• W2090758857 cites W2049085719 @default.
• W2090758857 cites W2049281642 @default.
• W2090758857 cites W2057279818 @default.
• W2090758857 cites W2057669829 @default.
• W2090758857 cites W2066356973 @default.
• W2090758857 cites W2069562157 @default.
• W2090758857 cites W2081560586 @default.
• W2090758857 cites W2096239313 @default.
• W2090758857 cites W2096946132 @default.
• W2090758857 cites W2104917184 @default.
• W2090758857 cites W2105348749 @default.
• W2090758857 cites W2109816625 @default.
• W2090758857 cites W2110875829 @default.
• W2090758857 cites W2117577687 @default.
• W2090758857 cites W2119836524 @default.
• W2090758857 cites W2126817554 @default.
• W2090758857 cites W2134942438 @default.
• W2090758857 cites W2138224523 @default.
• W2090758857 cites W2143078369 @default.
• W2090758857 cites W2146517909 @default.
• W2090758857 cites W2148977460 @default.
• W2090758857 cites W2154492710 @default.
• W2090758857 cites W2156545134 @default.
• W2090758857 cites W2160382843 @default.
• W2090758857 cites W2624094894 @default.
• W2090758857 doi "https://doi.org/10.1523/jneurosci.2977-14.2014" @default.
• W2090758857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6608431" @default.
• W2090758857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25355217" @default.
• W2090758857 hasPublicationYear "2014" @default.
• W2090758857 type Work @default.
• W2090758857 sameAs 2090758857 @default.
• W2090758857 citedByCount "42" @default.
• W2090758857 countsByYear W20907588572015 @default.
• W2090758857 countsByYear W20907588572016 @default.
• W2090758857 countsByYear W20907588572017 @default.
• W2090758857 countsByYear W20907588572018 @default.
• W2090758857 countsByYear W20907588572019 @default.
• W2090758857 countsByYear W20907588572020 @default.
• W2090758857 countsByYear W20907588572021 @default.
• W2090758857 countsByYear W20907588572022 @default.
• W2090758857 countsByYear W20907588572023 @default.
• W2090758857 crossrefType "journal-article" @default.
• W2090758857 hasAuthorship W2090758857A5000874395 @default.
• W2090758857 hasAuthorship W2090758857A5011954889 @default.
• W2090758857 hasAuthorship W2090758857A5021838367 @default.
• W2090758857 hasAuthorship W2090758857A5031828954 @default.
• W2090758857 hasAuthorship W2090758857A5047714102 @default.
• W2090758857 hasAuthorship W2090758857A5049016199 @default.
• W2090758857 hasAuthorship W2090758857A5066165135 @default.
• W2090758857 hasAuthorship W2090758857A5076104674 @default.
• W2090758857 hasBestOaLocation W20907588571 @default.
• W2090758857 hasConcept C104317684 @default.
• W2090758857 hasConcept C127716648 @default.
• W2090758857 hasConcept C142724271 @default.
• W2090758857 hasConcept C1491633281 @default.
• W2090758857 hasConcept C169760540 @default.
• W2090758857 hasConcept C2776985911 @default.
• W2090758857 hasConcept C2777931997 @default.
• W2090758857 hasConcept C2778227246 @default.
• W2090758857 hasConcept C2778609137 @default.
• W2090758857 hasConcept C2778880634 @default.
• W2090758857 hasConcept C2780265364 @default.
• W2090758857 hasConcept C2781246680 @default.
• W2090758857 hasConcept C2910969760 @default.
• W2090758857 hasConcept C502942594 @default.
• W2090758857 hasConcept C529278444 @default.
• W2090758857 hasConcept C54355233 @default.
• W2090758857 hasConcept C71924100 @default.
• W2090758857 hasConcept C86803240 @default.
• W2090758857 hasConceptScore W2090758857C104317684 @default.
• W2090758857 hasConceptScore W2090758857C127716648 @default.

• next