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• W2090765114 abstract "1. In high decerebrate rabbits, cells were sampled extracellularly from the rostral flocculus. Purkinje cells were identified by their characteristic responses to stimulation of the contralateral inferior olive. Identification of basket cells was based on the absence of olivary responses and also on their location in the molecular layer adjacent to identified Purkinje cells. Mass field potentials in the flocculus were also studied. 2. Single pulse stimulation of a vestibular nerve, either ipsilateral or contralateral, at a rate of 2/sec excited Purkinje cells with a latency of 3-6 msec. This early excitation represents activation through vestibular mossy fibres, granule cells and their axons (parallel fibres). Similar early excitation also occurred in putative basket cells. 3. Conjunctive stimulation of a vestibular nerve at 20/sec and the inferior olive at 4/sec, for 25 sec per trial, effectively depressed the early excitation of Purkinje cells by that nerve, without an associated change in spontaneous discharge. The depression recovered in about ten minutes. This recovery was followed by the onset of a slow depression lasting for an hour. 4. Conjunctive vestibular—olivary stimulation produced no such depression in the following responses: early excitation in Purkinje cells induced from the vestibular nerve not involved in the conjunctive stimulation; early excitation in putative basket cells from either vestibular nerve; inhibition or rebound facilitation in Purkinje cells following the early excitation; vestibular-evoked field potentials in the granular layer and white matter of the flocculus. These observations lead to the conclusion that the depression occurs specifically at parallel fibre—Purkinje cell synapses involved in conjunctive stimulation. 5. Ionophoretic application of glutamate to Purkinje cells in conjunction with 4/sec olivary stimulation depressed the glutamate sensitivity of Purkinje cells; aspartate sensitivity was depressed to a much lesser degree. The depression diminished in about 10 min, but this recovery was succeeded by a slow depression lasting for an hour. The depression was seen only when glutamate sensitivity was relatively high, suggesting that the micro-electrode was impinging onto Purkinje cell dendrites. These observations suggest that subsynaptic chemosensitivity of Purkinje cells to the putative neurotransmitter of parallel fibres is involved in the depression observed after conjunctive stimulation of a vestibular nerve and the inferior olive. 6. The present results are consistent with the Marr-Albus assumption concerning plasticity of cerebellar neuronal networks." @default.
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• W2090765114 date "1982-03-01" @default.
• W2090765114 modified "2023-10-15" @default.
• W2090765114 title "Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells" @default.
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• W2090765114 doi "https://doi.org/10.1113/jphysiol.1982.sp014103" @default.
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