FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090781457> ?p ?o ?g. }

• W2090781457 endingPage "321" @default.
• W2090781457 startingPage "309" @default.
• W2090781457 abstract "This study analyzes the nitrated protein profile of the rat-brain cortex in a model of hypoxia/reoxygenation, identifying the nitrated proteins and assessing spot changes. The proteins identified were grouped into categories, according to their function: 1) metabolism: pyruvate kinase (PK), α-enolase, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), phosphoglycerate mutase 1 (PGAM1), and glutamine synthetase (GS); 2) cytoskeletal proteins: α-tubulin, β-tubulin, γ-actin, and glial fibrillary acidic protein (GFAP); 3) chaperones: heat-shock protein 71kDa (HSP71); and 4) carrier proteins: voltage-dependent anion-selective channel protein 1 (VDAC-1) and Atp6v1a. PK, α-enolase, and GS nitration rates were upregulated, increasing progressively during reoxygenation and peaking at 24h. GAPDH and PGAM1 nitration levels fell after hypoxia/reoxygenation. α-Tubulin, β-tubulin, γ-actin, and GFAP nitration rates augmented at 24h, but diminished at 5d. HSP71 suffered from nitration immediately after hypoxia, but not during reoxygenation. VDAC-1 tyrosine nitration was identified only in the control group, whereas detectable Atp6v1a nitration levels were observed only immediately after hypoxia. The data have been deposited to the ProteomeXchange with identifier PXD001049. Our findings suggest a hypothetically crucial linkage between nitration-related protein modifications and metabolic and cell-structure alterations. These changes are probably needed for the remodeling and plasticity processes activated by the hypoxic brain response.For the first time the spectrum of nitrated proteins in the hypoxic brain as well as its changes during reoxygenation are described. Our findings suggest a hypothetically crucial linkage between nitration-related protein modifications and metabolic and cell-structure alterations. These changes are probably needed for the remodeling and plasticity processes activated by the hypoxic brain response. The biological relevance of these findings is linked to the important role developed by the signaling molecule NO in the hypoxic brain, and could be interpreted in two different but complementary ways: first, as a mechanism of damage due to nitration impacts over some key proteins affecting its structure and function; and second, as a regulation mechanism involved in the hypoxic response. Hence, based on the modified proteins identified and their functions, it would be possible to design new tools and therapies to prevent brain damage in low-oxygen-pressure atmospheres." @default.
• W2090781457 created "2016-06-24" @default.
• W2090781457 creator A5012387688 @default.
• W2090781457 creator A5023463626 @default.
• W2090781457 creator A5032205319 @default.
• W2090781457 creator A5079401219 @default.
• W2090781457 creator A5089070722 @default.
• W2090781457 creator A5091080257 @default.
• W2090781457 date "2014-09-01" @default.
• W2090781457 modified "2023-10-18" @default.
• W2090781457 title "Proteomic characterization of nitrated cell targets after hypobaric hypoxia and reoxygenation in rat brain" @default.
• W2090781457 cites W1505004726 @default.
• W2090781457 cites W1516157847 @default.
• W2090781457 cites W1525418428 @default.
• W2090781457 cites W1821918060 @default.
• W2090781457 cites W1877772679 @default.
• W2090781457 cites W1965707265 @default.
• W2090781457 cites W1967861550 @default.
• W2090781457 cites W1969773420 @default.
• W2090781457 cites W1969856763 @default.
• W2090781457 cites W1970184469 @default.
• W2090781457 cites W1971258279 @default.
• W2090781457 cites W1974403366 @default.
• W2090781457 cites W1978839418 @default.
• W2090781457 cites W1978969417 @default.
• W2090781457 cites W1980805550 @default.
• W2090781457 cites W1981326797 @default.
• W2090781457 cites W1981797064 @default.
• W2090781457 cites W1988230833 @default.
• W2090781457 cites W1990062639 @default.
• W2090781457 cites W1991101719 @default.
• W2090781457 cites W1993337204 @default.
• W2090781457 cites W1993570261 @default.
• W2090781457 cites W1995227276 @default.
• W2090781457 cites W2004483556 @default.
• W2090781457 cites W2006659891 @default.
• W2090781457 cites W2009279488 @default.
• W2090781457 cites W2009677832 @default.
• W2090781457 cites W2011394755 @default.
• W2090781457 cites W2013864534 @default.
• W2090781457 cites W2020219895 @default.
• W2090781457 cites W2022377100 @default.
• W2090781457 cites W2023559696 @default.
• W2090781457 cites W2024400556 @default.
• W2090781457 cites W2027705428 @default.
• W2090781457 cites W2030055154 @default.
• W2090781457 cites W2035760667 @default.
• W2090781457 cites W2040320750 @default.
• W2090781457 cites W2044776742 @default.
• W2090781457 cites W2054336997 @default.
• W2090781457 cites W2054546834 @default.
• W2090781457 cites W2054773659 @default.
• W2090781457 cites W2055609106 @default.
• W2090781457 cites W2055852420 @default.
• W2090781457 cites W2058997498 @default.
• W2090781457 cites W2059181444 @default.
• W2090781457 cites W2064175887 @default.
• W2090781457 cites W2064423385 @default.
• W2090781457 cites W2067195259 @default.
• W2090781457 cites W2071164054 @default.
• W2090781457 cites W2073987993 @default.
• W2090781457 cites W2076535162 @default.
• W2090781457 cites W2079822311 @default.
• W2090781457 cites W2083121123 @default.
• W2090781457 cites W2086526874 @default.
• W2090781457 cites W2086628740 @default.
• W2090781457 cites W2088439319 @default.
• W2090781457 cites W2088472356 @default.
• W2090781457 cites W2090563896 @default.
• W2090781457 cites W2090816846 @default.
• W2090781457 cites W2094213529 @default.
• W2090781457 cites W2094288745 @default.
• W2090781457 cites W2095991593 @default.
• W2090781457 cites W2097122412 @default.
• W2090781457 cites W2097513218 @default.
• W2090781457 cites W2098123322 @default.
• W2090781457 cites W2100837269 @default.
• W2090781457 cites W2106814023 @default.
• W2090781457 cites W2107243576 @default.
• W2090781457 cites W2107366065 @default.
• W2090781457 cites W2110223248 @default.
• W2090781457 cites W2124355926 @default.
• W2090781457 cites W2126782285 @default.
• W2090781457 cites W2126785007 @default.
• W2090781457 cites W2130393188 @default.
• W2090781457 cites W2131474149 @default.
• W2090781457 cites W2132747770 @default.
• W2090781457 cites W2135874321 @default.
• W2090781457 cites W2154142775 @default.
• W2090781457 cites W2157050521 @default.
• W2090781457 cites W2160935383 @default.
• W2090781457 cites W2164082141 @default.
• W2090781457 cites W2167632364 @default.
• W2090781457 cites W2167886264 @default.
• W2090781457 cites W2170295209 @default.
• W2090781457 cites W2179133093 @default.
• W2090781457 cites W2330379043 @default.
• W2090781457 cites W27216209 @default.

• next