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- W2090781503 abstract "We have examined the functional consequences induced by interaction of DR2a-restricted myelin basic protein (MBP) (87–99)-specific T cell clones (TCC) with altered peptide ligands (APL) derived from MBP peptide (87–99). The immunodominant MBP peptide (87–99) has been implicated as a candidate antigen in multiple sclerosis (MS) by several lines of evidence. In the present study, we have defined the T cell receptor (TCR) contact residues for DR2a-restricted, (87–99)-specific T helper type 1 T cells to design APL suitable to modify the functions of such T cells potentially relevant for the pathogenesis of MS. We show that neutral (L-alanine substitutions) or conservative exchanges of the primary and secondary TCR contact residues lead to various alterations of T cell function, ranging from differences in interleukin-2 receptor up-regulation to anergy induction and TCR antagonism. The potential usefulness of APL as an immunomodulating therapy for DR2+ MS patients is discussed." @default.
- W2090781503 created "2016-06-24" @default.
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- W2090781503 date "1996-11-01" @default.
- W2090781503 modified "2023-10-11" @default.
- W2090781503 title "Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87–99)" @default.
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- W2090781503 doi "https://doi.org/10.1002/eji.1830261113" @default.
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