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• W2090795434 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILPurpose: Melanoma only accounts for 4% of skin cancer while causing 75% of cancer related deaths. Also, the incidence is increasing with the annual percent change in the United States reported as 2.4% for the period 1986-2006 and currently increasing faster than any other cancer worldwide. Moreover, patients who develop locally advanced or metastatic melanoma have limited treatment options with 5-year survival rates of 65% and 16%, for regional disease and metastatic disease, respectively. Historically, melanoma was regarded as resistant to radiation therapy (RT), however, recently the utility of RT has been re-explored in the adjuvant setting with fractionated radiotherapy (FRT) and also in the oligometastatic setting with stereotactic radiotherapy (SBRT), and does show increase in local control in appropriately selected patients. The importance of microRNA (miRNA) in cancer continues to be elucidated and in melanoma they are extensively reported as having significant roles in melanoma transformation, progression, invasiveness, metastasis, and outcome/prognosis. However, there are no reports of melanoma miRNA profiling and RT. miRNA expression profiles change as a consequence of RT in several tumor types. Experiments show delivery of miRNA in vivo appears both feasible and tolerable in murine models. Additionally, correcting miRNA deregulation has been shown to mitigate the tumorigenic phenotype and also induce radiosensitivity in vitro and in vivo. Materials/Methods: We cultured more than a dozen melanoma cell lines and sequenced for mutations in key genes such as B-RAF, N-RAS, etc. to group them. Next we isolated their miRNA of untreated and treated with 6 Gray dose of radiation isolated at 5 days. The miRNA expression was quantified using RT-qPCR of TaqMan Low Density Arrays (TLDA) cards. The data is reported using hierarchical clustering and those miRNAs significantly deregulated have been delineated. Results/Discussion: We have characterized the miRNA expression profiles of melanoma cell lines when comparing untreated and those treated with radiation. Our data indicate that miRNA profiles done pre and post RT are significantly different. To this end we have identified clusters of miRNA associated with RT sensitivity/resistance. Thus, these miRNAs could be important factors in response to RT and their differential expression may be linked to resistance to RT. Consequently, it is conceivable that these miRNA and/or their mRNA targets could be used in the future as targets for drug development to radiosensitize melanoma and thus further improve outcomes.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5052. doi:1538-7445.AM2012-5052" @default.
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• W2090795434 date "2012-04-15" @default.
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• W2090795434 title "Abstract 5052: MicroRNA alterations following radiation in melanoma" @default.
• W2090795434 doi "https://doi.org/10.1158/1538-7445.am2012-5052" @default.
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