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• W2090800413 abstract "Cooperation between cadherins and the actin cytoskeleton controls the formation and maintenance of cell–cell adhesions in epithelia. We find that the molecular motor protein myosin-1c (Myo1c) regulates the dynamic stability of E-cadherin–based cell–cell contacts. In Myo1c-depleted Madin–Darby canine kidney cells, E-cadherin localization was dis­organized and lateral membranes appeared less vertical with convoluted edges versus control cells. In polarized monolayers, Myo1c-knockdown (KD) cells were more sensitive to reduced calcium concentration. Myo1c separated in the same plasma membrane fractions as E-cadherin, and Myo1c KD caused a significant reduction in the amount of E-cadherin recovered in one peak fraction. Expression of green fluorescent protein (GFP)–Myo1c mutants revealed that the phosphatidylinositol-4,5-bisphosphate–binding site is necessary for its localization to cell–cell adhesions, and fluorescence recovery after photobleaching assays with GFP-Myo1c mutants revealed that motor function was important for Myo1c dynamics at these sites. At 18°C, which inhibits vesicle recycling, Myo1c-KD cells accumulated more E-cadherin–positive vesicles in their cytoplasm, suggesting that Myo1c affects E-cadherin endocytosis. Studies with photoactivatable GFP–E-cadherin showed that Myo1c KD reduced the stability of E-cadherin at cell–cell adhesions. We conclude that Myo1c stabilizes E-cadherin at adherens junctions in polarized epithelial cells and that the motor function and ability of Myo1c to bind membrane are critical." @default.
• W2090800413 created "2016-06-24" @default.
• W2090800413 creator A5002133650 @default.
• W2090800413 creator A5071311509 @default.
• W2090800413 date "2013-09-15" @default.
• W2090800413 modified "2023-09-26" @default.
• W2090800413 title "Myosin-1c regulates the dynamic stability of E-cadherin–based cell–cell contacts in polarized Madin–Darby canine kidney cells" @default.
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• W2090800413 doi "https://doi.org/10.1091/mbc.e12-12-0884" @default.
• W2090800413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3771945" @default.
• W2090800413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23864705" @default.
• W2090800413 hasPublicationYear "2013" @default.
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