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• W2090800822 abstract "Citrullinated proteins have been suggested to play a critical role in the pathogenesis of multiple sclerosis (MS). Anticyclic citrullinated peptide (anti-CCP) antibody is used in the early diagnosis of rheumatoid arthritis (RA). The objective of this study was to investigate the presence of anti-CCP antibody in patients with MS compared to RA patients and healthy controls. Fifty patients with MS (38 females, 12 males; mean age 36.72 ± 8.82 years), 52 patients with RA (40 females, 12 males; mean age 40.87 ± 10.17 years), and 50 healthy controls (32 females, 18 males; mean age 38.22 ± 11.59 years) were included in this study. The levels of serum anti-CCP antibody were measured using an enzyme-linked immunosorbent assay (ELISA). The results of the study showed that anti-CCP antibody levels were significantly higher in RA patients versus MS or healthy controls<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mo stretchy=false>(</mml:mo><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>. Moreover, anti-CCP antibody was positive in 43 (83%) patients with RA, while it was negative in all MS patients as well as in all healthy controls. Also, no significant correlation was found between the anti-CCP levels and EDSS scores<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mo stretchy=false>(</mml:mo><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mo>-</mml:mo><mml:mn>0.250</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>. In conclusion, the results of this study did not support a positive association between serum anti-CCP antibody and MS." @default.
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• W2090800822 date "2015-01-01" @default.
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• W2090800822 title "Anti-CCP Antibody Levels Are Not Associated with MS: Results from a Case-Control Study" @default.
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• W2090800822 doi "https://doi.org/10.1155/2015/817427" @default.
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