FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090804929> ?p ?o ?g. }

• W2090804929 endingPage "604" @default.
• W2090804929 startingPage "594" @default.
• W2090804929 abstract "The authors investigated the feasibility of using injectable hydrogels, based on poly(N-isopropylacrylamide) (PNIPAAm), lightly cross-linked with polyethylene glycol (PEG) or methylcellulose (MC), to serve as injectable scaffolds for local delivery of neurotrophins and cellular transplants into the injured spinal cord. The primary aims of this work were to assess the biocompatibility of the scaffolds by evaluating graft cell survival and the host tissue immune response. The scaffolds were also evaluated for their ability to promote axonal growth through the action of released brain-derived neurotrophic factor (BDNF).The in vivo performance of PNIPAAm-g-PEG and PNIPAAm-g-MC was evaluated using a rodent model of spinal cord injury (SCI). The hydrogels were injected as viscous liquids into the injury site and formed space-filling hydrogels. The host immune response and biocompatibility of the scaffolds were evaluated at 2 weeks by histological and fluorescent immunohistochemical analysis. Commercially available matrices were used as a control and examined for comparison.Experiments showed that the scaffolds did not contribute to an injury-related inflammatory response. PNIPAAm-g-PEG was also shown to be an effective vehicle for delivery of cellular transplants and supported graft survival. Additionally, PNIPAAm-g-PEG and PNIPAAm-g-MC are permissive to axonal growth and can serve as injectable scaffolds for local delivery of BDNF.Based on the results, the authors suggest that these copolymers are feasible injectable scaffolds for cell grafting into the injured spinal cord and for delivery of therapeutic factors." @default.
• W2090804929 created "2016-06-24" @default.
• W2090804929 creator A5014636879 @default.
• W2090804929 creator A5034396354 @default.
• W2090804929 creator A5039839664 @default.
• W2090804929 creator A5059985761 @default.
• W2090804929 creator A5062648986 @default.
• W2090804929 creator A5073440135 @default.
• W2090804929 creator A5087153725 @default.
• W2090804929 date "2011-12-01" @default.
• W2090804929 modified "2023-10-05" @default.
• W2090804929 title "A pilot study of poly(N-isopropylacrylamide)-g-polyethylene glycol and poly(N-isopropylacrylamide)-g-methylcellulose branched copolymers as injectable scaffolds for local delivery of neurotrophins and cellular transplants into the injured spinal cord" @default.
• W2090804929 cites W1903157151 @default.
• W2090804929 cites W1965169108 @default.
• W2090804929 cites W1965352825 @default.
• W2090804929 cites W1967054754 @default.
• W2090804929 cites W1970002201 @default.
• W2090804929 cites W1970350515 @default.
• W2090804929 cites W1973303237 @default.
• W2090804929 cites W1978969724 @default.
• W2090804929 cites W1997722420 @default.
• W2090804929 cites W1999423147 @default.
• W2090804929 cites W1999881215 @default.
• W2090804929 cites W2004283213 @default.
• W2090804929 cites W2004668286 @default.
• W2090804929 cites W2006405705 @default.
• W2090804929 cites W2008508692 @default.
• W2090804929 cites W2009459640 @default.
• W2090804929 cites W2017025515 @default.
• W2090804929 cites W2031023695 @default.
• W2090804929 cites W2031875767 @default.
• W2090804929 cites W2032417465 @default.
• W2090804929 cites W2034436971 @default.
• W2090804929 cites W2035311358 @default.
• W2090804929 cites W2036883176 @default.
• W2090804929 cites W2037645967 @default.
• W2090804929 cites W2040673667 @default.
• W2090804929 cites W2054012520 @default.
• W2090804929 cites W2059653271 @default.
• W2090804929 cites W2063527175 @default.
• W2090804929 cites W2065507307 @default.
• W2090804929 cites W2067019666 @default.
• W2090804929 cites W2070050615 @default.
• W2090804929 cites W2080683593 @default.
• W2090804929 cites W2088406732 @default.
• W2090804929 cites W2091404665 @default.
• W2090804929 cites W2091998173 @default.
• W2090804929 cites W2093215475 @default.
• W2090804929 cites W2095301611 @default.
• W2090804929 cites W2104231587 @default.
• W2090804929 cites W2113724937 @default.
• W2090804929 cites W2117712478 @default.
• W2090804929 cites W2119845005 @default.
• W2090804929 cites W2123442007 @default.
• W2090804929 cites W2124749165 @default.
• W2090804929 cites W2144722561 @default.
• W2090804929 cites W2149286305 @default.
• W2090804929 cites W2152489651 @default.
• W2090804929 cites W2160274912 @default.
• W2090804929 cites W2170543194 @default.
• W2090804929 cites W2332136587 @default.
• W2090804929 cites W4298361955 @default.
• W2090804929 doi "https://doi.org/10.3171/2011.7.spine11194" @default.
• W2090804929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5025870" @default.
• W2090804929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21888482" @default.
• W2090804929 hasPublicationYear "2011" @default.
• W2090804929 type Work @default.
• W2090804929 sameAs 2090804929 @default.
• W2090804929 citedByCount "30" @default.
• W2090804929 countsByYear W20908049292012 @default.
• W2090804929 countsByYear W20908049292013 @default.
• W2090804929 countsByYear W20908049292014 @default.
• W2090804929 countsByYear W20908049292015 @default.
• W2090804929 countsByYear W20908049292016 @default.
• W2090804929 countsByYear W20908049292017 @default.
• W2090804929 countsByYear W20908049292018 @default.
• W2090804929 countsByYear W20908049292019 @default.
• W2090804929 countsByYear W20908049292020 @default.
• W2090804929 countsByYear W20908049292021 @default.
• W2090804929 countsByYear W20908049292022 @default.
• W2090804929 countsByYear W20908049292023 @default.
• W2090804929 crossrefType "journal-article" @default.
• W2090804929 hasAuthorship W2090804929A5014636879 @default.
• W2090804929 hasAuthorship W2090804929A5034396354 @default.
• W2090804929 hasAuthorship W2090804929A5039839664 @default.
• W2090804929 hasAuthorship W2090804929A5059985761 @default.
• W2090804929 hasAuthorship W2090804929A5062648986 @default.
• W2090804929 hasAuthorship W2090804929A5073440135 @default.
• W2090804929 hasAuthorship W2090804929A5087153725 @default.
• W2090804929 hasBestOaLocation W20908049291 @default.
• W2090804929 hasConcept C10138342 @default.
• W2090804929 hasConcept C108586683 @default.
• W2090804929 hasConcept C118552586 @default.
• W2090804929 hasConcept C136229726 @default.
• W2090804929 hasConcept C15920480 @default.
• W2090804929 hasConcept C159985019 @default.
• W2090804929 hasConcept C162324750 @default.
• W2090804929 hasConcept C178790620 @default.

• next