FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090809993> ?p ?o ?g. }

• W2090809993 endingPage "3219" @default.
• W2090809993 startingPage "3209" @default.
• W2090809993 abstract "Together with the NS5 polymerase, the NS3 helicase has a pivotal function in flavivirus RNA replication and constitutes an important drug target. We captured the dengue virus NS3 helicase at several stages along the catalytic pathway including bound to single-stranded (ss) RNA, to an ATP analogue, to a transition-state analogue and to ATP hydrolysis products. RNA recognition appears largely sequence independent in a way remarkably similar to eukaryotic DEAD box proteins Vasa and eIF4AIII. On ssRNA binding, the NS3 enzyme switches to a catalytic-competent state imparted by an inward movement of the P-loop, interdomain closure and a change in the divalent metal coordination shell, providing a structural basis for RNA-stimulated ATP hydrolysis. These structures demonstrate for the first time large quaternary changes in the flaviviridae helicase, identify the catalytic water molecule and point to a beta-hairpin that protrudes from subdomain 2, as a critical element for dsRNA unwinding. They also suggest how NS3 could exert an effect as an RNA-anchoring device and thus participate both in flavivirus RNA replication and assembly." @default.
• W2090809993 created "2016-06-24" @default.
• W2090809993 creator A5004817320 @default.
• W2090809993 creator A5010959547 @default.
• W2090809993 creator A5013154347 @default.
• W2090809993 creator A5022429604 @default.
• W2090809993 creator A5032121388 @default.
• W2090809993 creator A5032260576 @default.
• W2090809993 creator A5034479823 @default.
• W2090809993 creator A5047399913 @default.
• W2090809993 creator A5065520731 @default.
• W2090809993 creator A5065527770 @default.
• W2090809993 creator A5066510631 @default.
• W2090809993 creator A5068320814 @default.
• W2090809993 date "2008-11-13" @default.
• W2090809993 modified "2023-10-17" @default.
• W2090809993 title "Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein" @default.
• W2090809993 cites W1538074723 @default.
• W2090809993 cites W1582754056 @default.
• W2090809993 cites W1964571618 @default.
• W2090809993 cites W1971159715 @default.
• W2090809993 cites W1982003972 @default.
• W2090809993 cites W1986191025 @default.
• W2090809993 cites W1986496785 @default.
• W2090809993 cites W1992180542 @default.
• W2090809993 cites W1996984611 @default.
• W2090809993 cites W2000516676 @default.
• W2090809993 cites W2001641653 @default.
• W2090809993 cites W2017866593 @default.
• W2090809993 cites W2035595761 @default.
• W2090809993 cites W2038840577 @default.
• W2090809993 cites W2041008570 @default.
• W2090809993 cites W2046167970 @default.
• W2090809993 cites W2051502948 @default.
• W2090809993 cites W2052036458 @default.
• W2090809993 cites W2088059488 @default.
• W2090809993 cites W2091636398 @default.
• W2090809993 cites W2103321072 @default.
• W2090809993 cites W2105538224 @default.
• W2090809993 cites W2118272614 @default.
• W2090809993 cites W2118331279 @default.
• W2090809993 cites W2119473061 @default.
• W2090809993 cites W2122571070 @default.
• W2090809993 cites W2128535933 @default.
• W2090809993 cites W2129038392 @default.
• W2090809993 cites W2133161189 @default.
• W2090809993 cites W2134201060 @default.
• W2090809993 cites W2134682782 @default.
• W2090809993 cites W2136058787 @default.
• W2090809993 cites W2144081223 @default.
• W2090809993 cites W2155289314 @default.
• W2090809993 cites W2166288313 @default.
• W2090809993 doi "https://doi.org/10.1038/emboj.2008.232" @default.
• W2090809993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2599875" @default.
• W2090809993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19008861" @default.
• W2090809993 hasPublicationYear "2008" @default.
• W2090809993 type Work @default.
• W2090809993 sameAs 2090809993 @default.
• W2090809993 citedByCount "212" @default.
• W2090809993 countsByYear W20908099932012 @default.
• W2090809993 countsByYear W20908099932013 @default.
• W2090809993 countsByYear W20908099932014 @default.
• W2090809993 countsByYear W20908099932015 @default.
• W2090809993 countsByYear W20908099932016 @default.
• W2090809993 countsByYear W20908099932017 @default.
• W2090809993 countsByYear W20908099932018 @default.
• W2090809993 countsByYear W20908099932019 @default.
• W2090809993 countsByYear W20908099932020 @default.
• W2090809993 countsByYear W20908099932021 @default.
• W2090809993 countsByYear W20908099932022 @default.
• W2090809993 countsByYear W20908099932023 @default.
• W2090809993 crossrefType "journal-article" @default.
• W2090809993 hasAuthorship W2090809993A5004817320 @default.
• W2090809993 hasAuthorship W2090809993A5010959547 @default.
• W2090809993 hasAuthorship W2090809993A5013154347 @default.
• W2090809993 hasAuthorship W2090809993A5022429604 @default.
• W2090809993 hasAuthorship W2090809993A5032121388 @default.
• W2090809993 hasAuthorship W2090809993A5032260576 @default.
• W2090809993 hasAuthorship W2090809993A5034479823 @default.
• W2090809993 hasAuthorship W2090809993A5047399913 @default.
• W2090809993 hasAuthorship W2090809993A5065520731 @default.
• W2090809993 hasAuthorship W2090809993A5065527770 @default.
• W2090809993 hasAuthorship W2090809993A5066510631 @default.
• W2090809993 hasAuthorship W2090809993A5068320814 @default.
• W2090809993 hasBestOaLocation W20908099932 @default.
• W2090809993 hasConcept C104317684 @default.
• W2090809993 hasConcept C132379496 @default.
• W2090809993 hasConcept C159047783 @default.
• W2090809993 hasConcept C161223559 @default.
• W2090809993 hasConcept C166703698 @default.
• W2090809993 hasConcept C2191507 @default.
• W2090809993 hasConcept C2522874641 @default.
• W2090809993 hasConcept C2776408679 @default.
• W2090809993 hasConcept C2776449523 @default.
• W2090809993 hasConcept C2780568436 @default.
• W2090809993 hasConcept C41258723 @default.
• W2090809993 hasConcept C55493867 @default.
• W2090809993 hasConcept C67705224 @default.

• next