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• W2090816787 abstract "The aim of this study was to assess working memory (WM) in patients with major depressive disorder (MDD), using a robust parametric WM task (the n-back task). Twenty patients with MDD and twenty healthy controls completed a visual version of the paradigm, comprising four levels of task difficulty (i.e. 0-, 1-, 2-, and 3-back). Performance accuracy and reaction time (RT) were measured at each difficulty level. In comparison with controls, patients with MDD exhibited slower RTs (F(1,38) = 25.16, p < 0.001), and reduced accuracy (F(1,38) = 5.93, p < 0.001). There was no diagnosis-specific effect of task difficulty on performance accuracy. However, the faster response to memory (1–3-back) than to shadowing (0-back) tasks observed in controls was not as pronounced in patients. These observations support a relatively specific impairment of WM/central executive function in MDD, which may potentially mediate the diverse pattern of cognitive dysfunction noted in MDD. The parametric n-back task is applicable to subjects with MDD and yields results interpretable across the dimensions of task difficulty and performance in controls and patients." @default.
• W2090816787 created "2016-06-24" @default.
• W2090816787 creator A5002647521 @default.
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• W2090816787 date "2006-02-01" @default.
• W2090816787 modified "2023-10-16" @default.
• W2090816787 title "Pattern of impaired working memory during major depression" @default.
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• W2090816787 doi "https://doi.org/10.1016/j.jad.2005.11.003" @default.
• W2090816787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16364451" @default.
• W2090816787 hasPublicationYear "2006" @default.
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