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- W2090817962 abstract "Abstract 5-Fluorouracil (5-FU) treatment with large doses in adrenal-intact rats inhibited glucocorticoid induction of tryptophan oxygenase (TPO, EC 1.13.1.12) while simultaneously enhancing induction of hepatic tyrosine aminotransferase (TAT, EC 2.6.1.5). 5-FU treatment alone stimulated hepatic TAT several-fold in intact rats, and less so in adrenalectomized rats, while enhanced induction of TAT by 5-FU with glucocorticoids occurred equally well in adrenalectomized rats. Enhanced induction of TAT in 5-FU treated rats was not obtained if the primary inducer of TAT was insulin. The normal apparent half-life in vivo of glucocorticoid-induced TAT was 1.9 hr; this was increased to 3.9 hr by 5-FU cotreatment. These data support the likelihood that 5-FU supports TAT induction by altering the turnover in vivo of glucocorticoid-induced TAT." @default.
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- W2090817962 date "1971-09-01" @default.
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- W2090817962 title "Enhancement of hepatic tyrosine aminotransferase induction in the rat by 5-fluorouracil" @default.
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- W2090817962 doi "https://doi.org/10.1016/0006-2952(71)90223-1" @default.
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