FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090818946> ?p ?o ?g. }

• W2090818946 endingPage "649" @default.
• W2090818946 startingPage "635" @default.
• W2090818946 abstract "We investigated how the equine fetus prepares its pre-immune humoral repertoire for an imminent exposure to pathogens in the neonatal period, particularly how the primary hematopoietic organs are equipped to support B cell hematopoiesis and immunoglobulin (Ig) diversity. We demonstrated that the liver and the bone marrow at approximately 100 days of gestation (DG) are active sites of hematopoiesis based on the expression of signature messenger RNA (mRNA) (c-KIT, CD34, IL7R, CXCL12, IRF8, PU.1, PAX5, NOTCH1, GATA1, CEBPA) and protein markers (CD34, CD19, IgM, CD3, CD4, CD5, CD8, CD11b, CD172A) of hematopoietic development and leukocyte differentiation molecules, respectively. To verify Ig diversity achieved during the production of B cells, V(D)J segments were sequenced in primary lymphoid organs of the equine fetus and adult horse, revealing that similar heavy chain VDJ segments and CDR3 lengths were most frequently used independent of life stage. In contrast, different lambda light chain segments were predominant in equine fetal compared to adult stage, and surprisingly, the fetus had less restricted use of variable gene segments to construct the lambda chain. Fetal Igs also contained elements of sequence diversity, albeit to a smaller degree than that of the adult horse. Our data suggest that the B cells produced in the liver and bone marrow of the equine fetus generate a wide repertoire of pre-immune Igs for protection, and the more diverse use of different lambda variable gene segments in fetal life may provide the neonate an opportunity to respond to a wider range of antigens at birth." @default.
• W2090818946 created "2016-06-24" @default.
• W2090818946 creator A5045894508 @default.
• W2090818946 creator A5052991048 @default.
• W2090818946 creator A5061701685 @default.
• W2090818946 creator A5067035673 @default.
• W2090818946 date "2014-09-02" @default.
• W2090818946 modified "2023-10-16" @default.
• W2090818946 title "Hematopoiesis in the equine fetal liver suggests immune preparedness" @default.
• W2090818946 cites W1500186944 @default.
• W2090818946 cites W1506066615 @default.
• W2090818946 cites W1547994842 @default.
• W2090818946 cites W1561328814 @default.
• W2090818946 cites W1603837048 @default.
• W2090818946 cites W1610096280 @default.
• W2090818946 cites W1657952695 @default.
• W2090818946 cites W1769620789 @default.
• W2090818946 cites W1796828658 @default.
• W2090818946 cites W1909573815 @default.
• W2090818946 cites W1944728344 @default.
• W2090818946 cites W1969008892 @default.
• W2090818946 cites W1975868741 @default.
• W2090818946 cites W1977041541 @default.
• W2090818946 cites W1996791616 @default.
• W2090818946 cites W1998814931 @default.
• W2090818946 cites W2003140132 @default.
• W2090818946 cites W2004900118 @default.
• W2090818946 cites W2008546779 @default.
• W2090818946 cites W2012621186 @default.
• W2090818946 cites W2013734898 @default.
• W2090818946 cites W2015363531 @default.
• W2090818946 cites W2017533703 @default.
• W2090818946 cites W2022155148 @default.
• W2090818946 cites W2025805828 @default.
• W2090818946 cites W2029253498 @default.
• W2090818946 cites W2030294300 @default.
• W2090818946 cites W2031867844 @default.
• W2090818946 cites W2033701042 @default.
• W2090818946 cites W2036680344 @default.
• W2090818946 cites W2042096299 @default.
• W2090818946 cites W2045417932 @default.
• W2090818946 cites W2047145163 @default.
• W2090818946 cites W2049061896 @default.
• W2090818946 cites W2055573452 @default.
• W2090818946 cites W2056664397 @default.
• W2090818946 cites W2057065295 @default.
• W2090818946 cites W2058318049 @default.
• W2090818946 cites W2061285949 @default.
• W2090818946 cites W2064049779 @default.
• W2090818946 cites W2065698207 @default.
• W2090818946 cites W2067868839 @default.
• W2090818946 cites W2072404836 @default.
• W2090818946 cites W2075962787 @default.
• W2090818946 cites W2077053016 @default.
• W2090818946 cites W2078095517 @default.
• W2090818946 cites W2079405439 @default.
• W2090818946 cites W2081769332 @default.
• W2090818946 cites W2081870862 @default.
• W2090818946 cites W2082797461 @default.
• W2090818946 cites W2084492613 @default.
• W2090818946 cites W2084987250 @default.
• W2090818946 cites W2087438783 @default.
• W2090818946 cites W2091477384 @default.
• W2090818946 cites W2091879808 @default.
• W2090818946 cites W2094827208 @default.
• W2090818946 cites W2114423378 @default.
• W2090818946 cites W2117174491 @default.
• W2090818946 cites W2122140726 @default.
• W2090818946 cites W2125830784 @default.
• W2090818946 cites W2127552260 @default.
• W2090818946 cites W2127851311 @default.
• W2090818946 cites W2135029910 @default.
• W2090818946 cites W2156856630 @default.
• W2090818946 cites W2166451951 @default.
• W2090818946 cites W2168015227 @default.
• W2090818946 cites W2169593696 @default.
• W2090818946 cites W2171690009 @default.
• W2090818946 cites W2327710116 @default.
• W2090818946 cites W2578150941 @default.
• W2090818946 cites W50651563 @default.
• W2090818946 doi "https://doi.org/10.1007/s00251-014-0799-9" @default.
• W2090818946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4198492" @default.
• W2090818946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25179685" @default.
• W2090818946 hasPublicationYear "2014" @default.
• W2090818946 type Work @default.
• W2090818946 sameAs 2090818946 @default.
• W2090818946 citedByCount "14" @default.
• W2090818946 countsByYear W20908189462016 @default.
• W2090818946 countsByYear W20908189462017 @default.
• W2090818946 countsByYear W20908189462018 @default.
• W2090818946 countsByYear W20908189462019 @default.
• W2090818946 countsByYear W20908189462020 @default.
• W2090818946 countsByYear W20908189462021 @default.
• W2090818946 countsByYear W20908189462022 @default.
• W2090818946 countsByYear W20908189462023 @default.
• W2090818946 crossrefType "journal-article" @default.
• W2090818946 hasAuthorship W2090818946A5045894508 @default.
• W2090818946 hasAuthorship W2090818946A5052991048 @default.

• next