FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090822134> ?p ?o ?g. }

• W2090822134 endingPage "304" @default.
• W2090822134 startingPage "289" @default.
• W2090822134 abstract "This study evaluates possible circadian rhythms during prolonged propofol infusion in patients in the intensive care unit. Eleven patients were sedated with a constant propofol infusion. The blood samples for the propofol assay were collected every hour during the second day, the third day, and after the termination of the propofol infusion. Values of electroencephalographic bispectral index (BIS), arterial blood pressure, heart rate, blood oxygen saturation and body temperature were recorded every hour at the blood collection time points. A two-compartment model was used to describe propofol pharmacokinetics. Typical values of the central and peripheral volume of distribution and inter-compartmental clearance were V C = 27.7 l, V T = 801 l, and CL D = 2.73 l/min. The systolic blood pressure (SBP) was found to influence the propofol metabolic clearance according to Cl (l/min) = 2.65·(1 − 0.00714·(SBP − 135)). There was no significant circadian rhythm detected with respect to propofol pharmacokinetics. The BIS score was assessed as a direct effect model with EC 50 equal 1.98 mg/l. There was no significant circadian rhythm detected within the BIS scores. We concluded that the light–dark cycle did not influence propofol pharmacokinetics and pharmacodynamics in intensive care units patients. The lack of night–day differences was also noted for systolic blood pressure, diastolic blood pressure and blood oxygenation. Circadian rhythms were detected for heart rate and body temperature, however they were severely disturbed from the pattern of healthy patients." @default.
• W2090822134 created "2016-06-24" @default.
• W2090822134 creator A5000016260 @default.
• W2090822134 creator A5009926878 @default.
• W2090822134 creator A5021411163 @default.
• W2090822134 creator A5021754483 @default.
• W2090822134 creator A5035028627 @default.
• W2090822134 creator A5040519855 @default.
• W2090822134 creator A5047337599 @default.
• W2090822134 creator A5066340597 @default.
• W2090822134 creator A5073842264 @default.
• W2090822134 creator A5079584292 @default.
• W2090822134 date "2010-06-01" @default.
• W2090822134 modified "2023-10-16" @default.
• W2090822134 title "Assessing circadian rhythms in propofol PK and PD during prolonged infusion in ICU patients" @default.
• W2090822134 cites W13667623 @default.
• W2090822134 cites W1883140844 @default.
• W2090822134 cites W1966147053 @default.
• W2090822134 cites W1970852057 @default.
• W2090822134 cites W1974596067 @default.
• W2090822134 cites W1980840327 @default.
• W2090822134 cites W1980959248 @default.
• W2090822134 cites W1984392358 @default.
• W2090822134 cites W1987515299 @default.
• W2090822134 cites W1995385656 @default.
• W2090822134 cites W1996657690 @default.
• W2090822134 cites W2007783553 @default.
• W2090822134 cites W2020684605 @default.
• W2090822134 cites W2022795090 @default.
• W2090822134 cites W2032131160 @default.
• W2090822134 cites W2034180934 @default.
• W2090822134 cites W2039257965 @default.
• W2090822134 cites W2040327687 @default.
• W2090822134 cites W2049289092 @default.
• W2090822134 cites W2053253235 @default.
• W2090822134 cites W2056635372 @default.
• W2090822134 cites W2058979451 @default.
• W2090822134 cites W2060357972 @default.
• W2090822134 cites W2071917286 @default.
• W2090822134 cites W2072486211 @default.
• W2090822134 cites W2072870313 @default.
• W2090822134 cites W2074068229 @default.
• W2090822134 cites W2074671627 @default.
• W2090822134 cites W2081876792 @default.
• W2090822134 cites W2090307551 @default.
• W2090822134 cites W2098745184 @default.
• W2090822134 cites W2108296889 @default.
• W2090822134 cites W2161388412 @default.
• W2090822134 cites W2161408256 @default.
• W2090822134 cites W2171742215 @default.
• W2090822134 cites W2329274945 @default.
• W2090822134 cites W4248644417 @default.
• W2090822134 doi "https://doi.org/10.1007/s10928-010-9161-5" @default.
• W2090822134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2889282" @default.
• W2090822134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20544262" @default.
• W2090822134 hasPublicationYear "2010" @default.
• W2090822134 type Work @default.
• W2090822134 sameAs 2090822134 @default.
• W2090822134 citedByCount "20" @default.
• W2090822134 countsByYear W20908221342012 @default.
• W2090822134 countsByYear W20908221342013 @default.
• W2090822134 countsByYear W20908221342014 @default.
• W2090822134 countsByYear W20908221342015 @default.
• W2090822134 countsByYear W20908221342016 @default.
• W2090822134 countsByYear W20908221342017 @default.
• W2090822134 countsByYear W20908221342018 @default.
• W2090822134 countsByYear W20908221342020 @default.
• W2090822134 countsByYear W20908221342021 @default.
• W2090822134 countsByYear W20908221342022 @default.
• W2090822134 crossrefType "journal-article" @default.
• W2090822134 hasAuthorship W2090822134A5000016260 @default.
• W2090822134 hasAuthorship W2090822134A5009926878 @default.
• W2090822134 hasAuthorship W2090822134A5021411163 @default.
• W2090822134 hasAuthorship W2090822134A5021754483 @default.
• W2090822134 hasAuthorship W2090822134A5035028627 @default.
• W2090822134 hasAuthorship W2090822134A5040519855 @default.
• W2090822134 hasAuthorship W2090822134A5047337599 @default.
• W2090822134 hasAuthorship W2090822134A5066340597 @default.
• W2090822134 hasAuthorship W2090822134A5073842264 @default.
• W2090822134 hasAuthorship W2090822134A5079584292 @default.
• W2090822134 hasBestOaLocation W20908221341 @default.
• W2090822134 hasConcept C111113717 @default.
• W2090822134 hasConcept C112705442 @default.
• W2090822134 hasConcept C121446783 @default.
• W2090822134 hasConcept C126322002 @default.
• W2090822134 hasConcept C2776277131 @default.
• W2090822134 hasConcept C2777953023 @default.
• W2090822134 hasConcept C2779537118 @default.
• W2090822134 hasConcept C2781097354 @default.
• W2090822134 hasConcept C42219234 @default.
• W2090822134 hasConcept C71924100 @default.
• W2090822134 hasConcept C84393581 @default.
• W2090822134 hasConceptScore W2090822134C111113717 @default.
• W2090822134 hasConceptScore W2090822134C112705442 @default.
• W2090822134 hasConceptScore W2090822134C121446783 @default.
• W2090822134 hasConceptScore W2090822134C126322002 @default.
• W2090822134 hasConceptScore W2090822134C2776277131 @default.
• W2090822134 hasConceptScore W2090822134C2777953023 @default.

• next