FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090824895> ?p ?o ?g. }

• W2090824895 endingPage "234" @default.
• W2090824895 startingPage "224" @default.
• W2090824895 abstract "In the majority of breast cancers, overexpression and hyperactivation of Ras in the tumor microenvironment play significant role in promoting cancer cell growth, angiogenesis, and metastasis. We have previously shown that vascular endothelial growth factor (VEGF) expression in triple negative breast cancer cells is regulated, at least in part, by SAF-1 (serum amyloid A activating factor 1) transcription factor. In this study we show that transformation of normal MCF-10A breast epithelial cells by constitutively active, oncogenic Ras, induces the DNA-binding activity and transcription function of SAF-1. Furthermore, we show that inhibition of MEK/MAPK-signaling pathway prevents Ras-mediated activation of SAF-1. Interestingly, silencing of SAF-1 expression in breast cancer cells by SAF-1-specific short hairpin RNAs (shRNAs) significantly reduced H-Ras and K-Ras mRNA level. We show that SAF-1 is a direct transcriptional regulator of H-Ras and K-Ras and overexpression of SAF-1 increases H-Ras and K-Ras gene expression. Chromatin immunoprecipitation (ChIP) analyses demonstrated in vivo interaction of SAF-1 at highly purine-rich sequences present at the proximal promoter region, upstream of the transcription start site, in H-Ras and K-Ras genes. Previous studies have shown that these sequences are nuclease hypersensitive and capable of forming G4 quadruplex structure. Together, our results show the presence of a novel transactivating loop, in which, Ras and SAF-1 are interconnected. These findings will help defining molecular mechanisms of abnormal overexpression of Ras in breast tumors, which seldom show genetic Ras mutations." @default.
• W2090824895 created "2016-06-24" @default.
• W2090824895 creator A5020111511 @default.
• W2090824895 creator A5023928408 @default.
• W2090824895 date "2014-11-30" @default.
• W2090824895 modified "2023-10-12" @default.
• W2090824895 title "Induction of Ras by <scp>SAF</scp> ‐1/ <scp>MAZ</scp> through a feed‐forward loop promotes angiogenesis in breast cancer" @default.
• W2090824895 cites W1508497000 @default.
• W2090824895 cites W1520438304 @default.
• W2090824895 cites W1535504983 @default.
• W2090824895 cites W1598659248 @default.
• W2090824895 cites W1896854564 @default.
• W2090824895 cites W1985238450 @default.
• W2090824895 cites W1985821841 @default.
• W2090824895 cites W2006525926 @default.
• W2090824895 cites W2007916146 @default.
• W2090824895 cites W2010882280 @default.
• W2090824895 cites W2016167564 @default.
• W2090824895 cites W2020733170 @default.
• W2090824895 cites W2022213176 @default.
• W2090824895 cites W2022979064 @default.
• W2090824895 cites W2035539254 @default.
• W2090824895 cites W2042040883 @default.
• W2090824895 cites W2042371773 @default.
• W2090824895 cites W2043553889 @default.
• W2090824895 cites W2043901294 @default.
• W2090824895 cites W2050913592 @default.
• W2090824895 cites W2051371527 @default.
• W2090824895 cites W2063627291 @default.
• W2090824895 cites W2067768430 @default.
• W2090824895 cites W2074151784 @default.
• W2090824895 cites W2074584135 @default.
• W2090824895 cites W2075359755 @default.
• W2090824895 cites W2083703501 @default.
• W2090824895 cites W2083971873 @default.
• W2090824895 cites W2087411126 @default.
• W2090824895 cites W2087523741 @default.
• W2090824895 cites W2089310643 @default.
• W2090824895 cites W2091644035 @default.
• W2090824895 cites W2093530104 @default.
• W2090824895 cites W2097322288 @default.
• W2090824895 cites W2097382995 @default.
• W2090824895 cites W2101882577 @default.
• W2090824895 cites W2104454005 @default.
• W2090824895 cites W2113309844 @default.
• W2090824895 cites W2117282734 @default.
• W2090824895 cites W2120014985 @default.
• W2090824895 cites W2131441612 @default.
• W2090824895 cites W2132601924 @default.
• W2090824895 cites W2146651717 @default.
• W2090824895 cites W2152618829 @default.
• W2090824895 cites W2153067410 @default.
• W2090824895 cites W2159594827 @default.
• W2090824895 cites W2167052418 @default.
• W2090824895 cites W2171830519 @default.
• W2090824895 cites W4232777855 @default.
• W2090824895 cites W4235333461 @default.
• W2090824895 doi "https://doi.org/10.1002/cam4.362" @default.
• W2090824895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4329006" @default.
• W2090824895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25449683" @default.
• W2090824895 hasPublicationYear "2014" @default.
• W2090824895 type Work @default.
• W2090824895 sameAs 2090824895 @default.
• W2090824895 citedByCount "22" @default.
• W2090824895 countsByYear W20908248952015 @default.
• W2090824895 countsByYear W20908248952016 @default.
• W2090824895 countsByYear W20908248952017 @default.
• W2090824895 countsByYear W20908248952018 @default.
• W2090824895 countsByYear W20908248952019 @default.
• W2090824895 countsByYear W20908248952021 @default.
• W2090824895 countsByYear W20908248952022 @default.
• W2090824895 countsByYear W20908248952023 @default.
• W2090824895 crossrefType "journal-article" @default.
• W2090824895 hasAuthorship W2090824895A5020111511 @default.
• W2090824895 hasAuthorship W2090824895A5023928408 @default.
• W2090824895 hasBestOaLocation W20908248951 @default.
• W2090824895 hasConcept C101762097 @default.
• W2090824895 hasConcept C104317684 @default.
• W2090824895 hasConcept C119056186 @default.
• W2090824895 hasConcept C134320426 @default.
• W2090824895 hasConcept C150194340 @default.
• W2090824895 hasConcept C153911025 @default.
• W2090824895 hasConcept C173396325 @default.
• W2090824895 hasConcept C185592680 @default.
• W2090824895 hasConcept C190232843 @default.
• W2090824895 hasConcept C2780394083 @default.
• W2090824895 hasConcept C502942594 @default.
• W2090824895 hasConcept C54355233 @default.
• W2090824895 hasConcept C57074206 @default.
• W2090824895 hasConcept C62478195 @default.
• W2090824895 hasConcept C86339819 @default.
• W2090824895 hasConcept C86803240 @default.
• W2090824895 hasConcept C95444343 @default.
• W2090824895 hasConceptScore W2090824895C101762097 @default.
• W2090824895 hasConceptScore W2090824895C104317684 @default.
• W2090824895 hasConceptScore W2090824895C119056186 @default.
• W2090824895 hasConceptScore W2090824895C134320426 @default.
• W2090824895 hasConceptScore W2090824895C150194340 @default.

• next