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• W2090826718 endingPage "721" @default.
• W2090826718 startingPage "710" @default.
• W2090826718 abstract "Postsynaptic intracellular Ca(2+) concentration ([Ca(2+)](i)) has been proposed to play an important role in both synaptic plasticity and synaptic homeostasis. In particular, postsynaptic Ca(2+) signals can alter synaptic efficacy by influencing transmitter release, receptor sensitivity, and protein synthesis. We examined the postsynaptic Ca(2+) transients at the Drosophila larval neuromuscular junction (NMJ) by injecting the muscle fibers with Ca(2+) indicators rhod-2 and Oregon Green BAPTA-1 (OGB-1) and then monitoring their increased fluorescence during synaptic activity. We observed discrete postsynaptic Ca(2+) transients along the NMJ during single action potentials (APs) and quantal Ca(2+) transients produced by spontaneous transmitter release. Most of the evoked Ca(2+) transients resulted from the release of one or two quanta of transmitter and occurred largely at synaptic boutons. The magnitude of the Ca(2+) signals was correlated with synaptic efficacy; the Is terminals, which produce larger excitatory postsynaptic potentials (EPSPs) and have a greater quantal size than Ib terminals, produced a larger Ca(2+) signal per terminal length and larger quantal Ca(2+) signals than the Ib terminals. During a train of APs, the postsynaptic Ca(2+) signal increased but remained localized to the postsynaptic membrane. In addition, we showed that the plasma membrane Ca(2+)-ATPase (PMCA) played a role in extruding Ca(2+) from the postsynaptic region of the muscle. Drosophila melanogaster has a single PMCA gene, predicted to give rise to various isoforms by alternative splicing. Using RT-PCR, we detected the expression of multiple transcripts in muscle and nervous tissues; the physiological significance of the same is yet to be determined." @default.
• W2090826718 created "2016-06-24" @default.
• W2090826718 creator A5043145171 @default.
• W2090826718 creator A5074650601 @default.
• W2090826718 date "2011-08-01" @default.
• W2090826718 modified "2023-09-27" @default.
• W2090826718 title "Characterization of postsynaptic Ca²⁺signals at the<i>Drosophila</i>larval NMJ" @default.
• W2090826718 cites W1482593432 @default.
• W2090826718 cites W1506710296 @default.
• W2090826718 cites W1510879979 @default.
• W2090826718 cites W1513600037 @default.
• W2090826718 cites W1534752637 @default.
• W2090826718 cites W1550281689 @default.
• W2090826718 cites W1553130132 @default.
• W2090826718 cites W1579870050 @default.
• W2090826718 cites W1588765091 @default.
• W2090826718 cites W1603617892 @default.
• W2090826718 cites W1626000963 @default.
• W2090826718 cites W1669322589 @default.
• W2090826718 cites W1955231649 @default.
• W2090826718 cites W1957331510 @default.
• W2090826718 cites W1965265446 @default.
• W2090826718 cites W1970729216 @default.
• W2090826718 cites W1970889111 @default.
• W2090826718 cites W1977912923 @default.
• W2090826718 cites W1981597576 @default.
• W2090826718 cites W1992185775 @default.
• W2090826718 cites W1994348876 @default.
• W2090826718 cites W1995136282 @default.
• W2090826718 cites W1995484013 @default.
• W2090826718 cites W2001957253 @default.
• W2090826718 cites W2002027111 @default.
• W2090826718 cites W2005289903 @default.
• W2090826718 cites W2007239742 @default.
• W2090826718 cites W2008157904 @default.
• W2090826718 cites W2012433213 @default.
• W2090826718 cites W2014034588 @default.
• W2090826718 cites W2014722170 @default.
• W2090826718 cites W2031779883 @default.
• W2090826718 cites W2031898618 @default.
• W2090826718 cites W2032653771 @default.
• W2090826718 cites W2034513993 @default.
• W2090826718 cites W2038666250 @default.
• W2090826718 cites W2040812558 @default.
• W2090826718 cites W2042604124 @default.
• W2090826718 cites W2047833156 @default.
• W2090826718 cites W2055518516 @default.
• W2090826718 cites W2060631884 @default.
• W2090826718 cites W2065178022 @default.
• W2090826718 cites W2066994490 @default.
• W2090826718 cites W2071357317 @default.
• W2090826718 cites W2074284357 @default.
• W2090826718 cites W2081610534 @default.
• W2090826718 cites W2082372907 @default.
• W2090826718 cites W2084840477 @default.
• W2090826718 cites W2084922329 @default.
• W2090826718 cites W2085270288 @default.
• W2090826718 cites W2085615315 @default.
• W2090826718 cites W2086317178 @default.
• W2090826718 cites W2089184936 @default.
• W2090826718 cites W2090948229 @default.
• W2090826718 cites W2093573816 @default.
• W2090826718 cites W2100837269 @default.
• W2090826718 cites W2101108802 @default.
• W2090826718 cites W2101336937 @default.
• W2090826718 cites W2109851824 @default.
• W2090826718 cites W2110643873 @default.
• W2090826718 cites W2121436391 @default.
• W2090826718 cites W2126814404 @default.
• W2090826718 cites W2128106111 @default.
• W2090826718 cites W2128703002 @default.
• W2090826718 cites W2135710940 @default.
• W2090826718 cites W2137433892 @default.
• W2090826718 cites W2145050378 @default.
• W2090826718 cites W2145791439 @default.
• W2090826718 cites W2153060249 @default.
• W2090826718 cites W2155368843 @default.
• W2090826718 cites W2159750330 @default.
• W2090826718 cites W2160769038 @default.
• W2090826718 cites W2168553595 @default.
• W2090826718 cites W2176061808 @default.
• W2090826718 cites W2918025614 @default.
• W2090826718 cites W4229913877 @default.
• W2090826718 cites W4233014035 @default.
• W2090826718 doi "https://doi.org/10.1152/jn.00045.2011" @default.
• W2090826718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21593388" @default.
• W2090826718 hasPublicationYear "2011" @default.
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