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- W2090836500 abstract "Significance Antibody production depends on a cut-and-paste genomic rearrangement termed “V(D)J recombination” that takes place during early B-lymphocyte development. Mistakes in V(D)J recombination can lead to chromosomal translocations that activate oncogenes. Such mistakes usually lead to immature B-cell cancers. However, in the absence of the ATM kinase, mice can develop mature B-cell tumors with translocations resulting from V(D)J recombination-associated breaks. Normally persistent chromosome breaks activate cellular checkpoints that eliminate cells harboring such dangerous lesions. The current studies reveal that, in the absence of ATM, V(D)J recombination-generated breaks are cycled into aberrant chromosomes, termed “dicentrics,” that avoid checkpoints and are propagated through development, generating new breaks and translocations in mature B cells." @default.
- W2090836500 created "2016-06-24" @default.
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- W2090836500 date "2014-06-30" @default.
- W2090836500 modified "2023-09-25" @default.
- W2090836500 title "Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes" @default.
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- W2090836500 doi "https://doi.org/10.1073/pnas.1410112111" @default.
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