FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090837780> ?p ?o ?g. }

• W2090837780 endingPage "3084" @default.
• W2090837780 startingPage "3074" @default.
• W2090837780 abstract "High altitude pulmonary oedema (HAPE) severely affects non-acclimatized individuals and is characterized by alveolar flooding with protein-rich oedema as a consequence of blood-gas barrier disruption. Limited choice for prophylactic treatment warrants effective therapy against HAPE. Keratinocyte growth factor-2 (KGF-2) has shown efficiency in preventing alveolar epithelial cell DNA damages in vitro. In the current study, the effects of KGF-2 intratracheal instillation on mortality, lung liquid balance and lung histology were evaluated in our previously developed rat model of HAPE. We found that pre-treatment with KGF-2 (5 mg/kg) significantly decreased mortality, improved oxygenation and reduced lung wet-to-dry weight ratio by preventing alveolar-capillary barrier disruption demonstrated by histological examination and increasing alveolar fluid clearance up to 150%. In addition, KGF-2 significantly inhibited decrease of transendothelial permeability after exposure to hypoxia, accompanied by a 10-fold increase of Akt activity and inhibited apoptosis in human pulmonary microvascular endothelial cells, demonstrating attenuated endothelial apoptosis might contribute to reduction of endothelial permeability. These results showed the efficacy of KGF-2 on inhibition of endothelial cell apoptosis, preservation of alveolar-capillary barrier integrity and promotion of pulmonary oedema absorption in HAPE. Thus, KGF-2 may represent a potential drug candidate for the prevention of HAPE." @default.
• W2090837780 created "2016-06-24" @default.
• W2090837780 creator A5014145916 @default.
• W2090837780 creator A5015366379 @default.
• W2090837780 creator A5053429222 @default.
• W2090837780 creator A5054883051 @default.
• W2090837780 creator A5063163553 @default.
• W2090837780 creator A5068465620 @default.
• W2090837780 creator A5074439380 @default.
• W2090837780 creator A5091295838 @default.
• W2090837780 date "2012-12-01" @default.
• W2090837780 modified "2023-10-02" @default.
• W2090837780 title "KGF-2 targets alveolar epithelia and capillary endothelia to reduce high altitude pulmonary oedema in rats" @default.
• W2090837780 cites W1879497209 @default.
• W2090837780 cites W1921795167 @default.
• W2090837780 cites W1977637474 @default.
• W2090837780 cites W1983770773 @default.
• W2090837780 cites W1994008133 @default.
• W2090837780 cites W1996160336 @default.
• W2090837780 cites W2000192704 @default.
• W2090837780 cites W2000724701 @default.
• W2090837780 cites W2006182674 @default.
• W2090837780 cites W2011037002 @default.
• W2090837780 cites W2024234012 @default.
• W2090837780 cites W2025430232 @default.
• W2090837780 cites W2029636839 @default.
• W2090837780 cites W2039603495 @default.
• W2090837780 cites W2042577267 @default.
• W2090837780 cites W2046827519 @default.
• W2090837780 cites W2071924008 @default.
• W2090837780 cites W2075430896 @default.
• W2090837780 cites W2081394769 @default.
• W2090837780 cites W2082514775 @default.
• W2090837780 cites W2083364047 @default.
• W2090837780 cites W2093182170 @default.
• W2090837780 cites W2097483508 @default.
• W2090837780 cites W2101358905 @default.
• W2090837780 cites W2101496432 @default.
• W2090837780 cites W2107225910 @default.
• W2090837780 cites W2110481581 @default.
• W2090837780 cites W2110850407 @default.
• W2090837780 cites W2114703597 @default.
• W2090837780 cites W2118044708 @default.
• W2090837780 cites W2125921102 @default.
• W2090837780 cites W2141627633 @default.
• W2090837780 cites W2145996634 @default.
• W2090837780 cites W2147111676 @default.
• W2090837780 cites W2150858502 @default.
• W2090837780 cites W2152280553 @default.
• W2090837780 cites W2153563000 @default.
• W2090837780 cites W2156994947 @default.
• W2090837780 cites W2158335646 @default.
• W2090837780 cites W2166589605 @default.
• W2090837780 cites W2168784077 @default.
• W2090837780 cites W2175740141 @default.
• W2090837780 cites W2188627635 @default.
• W2090837780 cites W2129623190 @default.
• W2090837780 doi "https://doi.org/10.1111/j.1582-4934.2012.01588.x" @default.
• W2090837780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4393735" @default.
• W2090837780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22568566" @default.
• W2090837780 hasPublicationYear "2012" @default.
• W2090837780 type Work @default.
• W2090837780 sameAs 2090837780 @default.
• W2090837780 citedByCount "29" @default.
• W2090837780 countsByYear W20908377802013 @default.
• W2090837780 countsByYear W20908377802014 @default.
• W2090837780 countsByYear W20908377802015 @default.
• W2090837780 countsByYear W20908377802016 @default.
• W2090837780 countsByYear W20908377802017 @default.
• W2090837780 countsByYear W20908377802018 @default.
• W2090837780 countsByYear W20908377802019 @default.
• W2090837780 countsByYear W20908377802020 @default.
• W2090837780 countsByYear W20908377802021 @default.
• W2090837780 countsByYear W20908377802022 @default.
• W2090837780 countsByYear W20908377802023 @default.
• W2090837780 crossrefType "journal-article" @default.
• W2090837780 hasAuthorship W2090837780A5014145916 @default.
• W2090837780 hasAuthorship W2090837780A5015366379 @default.
• W2090837780 hasAuthorship W2090837780A5053429222 @default.
• W2090837780 hasAuthorship W2090837780A5054883051 @default.
• W2090837780 hasAuthorship W2090837780A5063163553 @default.
• W2090837780 hasAuthorship W2090837780A5068465620 @default.
• W2090837780 hasAuthorship W2090837780A5074439380 @default.
• W2090837780 hasAuthorship W2090837780A5091295838 @default.
• W2090837780 hasBestOaLocation W20908377802 @default.
• W2090837780 hasConcept C113045295 @default.
• W2090837780 hasConcept C126322002 @default.
• W2090837780 hasConcept C134018914 @default.
• W2090837780 hasConcept C142724271 @default.
• W2090837780 hasConcept C170493617 @default.
• W2090837780 hasConcept C178790620 @default.
• W2090837780 hasConcept C185592680 @default.
• W2090837780 hasConcept C190283241 @default.
• W2090837780 hasConcept C2776468924 @default.
• W2090837780 hasConcept C2777714996 @default.
• W2090837780 hasConcept C2778615670 @default.
• W2090837780 hasConcept C540031477 @default.
• W2090837780 hasConcept C55493867 @default.

• next