Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090844093> ?p ?o ?g. }
- W2090844093 endingPage "2116" @default.
- W2090844093 startingPage "2105" @default.
- W2090844093 abstract "Objective: To evaluate the anti-fibrotic effects of Astragaloside IV in systemic sclerosis. Methods: Treated or untreated systemic sclerosis (SSc) and normal fibroblast isolated from corresponding pairs were utilized to detect expression of collagen and fibronectin by western blot, quantitative real-time RT-PCR (RT-qPCR), immunofluorescence staining and histopathological examination. SSc mouse model induced by bleomycin was used to evaluate the effects of the drug in vivo. Results: Compared to normal fibroblast (NF), the expression of collagen and fibronectin in SSc (SScF) dramatically increased, and this could be reduced by Astragaloside IV (AST) in a dose- or time-dependent manner at both protein and mRNA levels. Administration of Astragaloside IV consistently decreased collagen formation and partially restored the structure, as well as suppressing collagen and fibronectin expression in the skin lesions of SSc-model mice. Mechanistically, Astragaloside IV-induced fibrosis reduction may be due to deregulation of Smad 3/Fli-1, the major mediators of the fibrotic response and key molecules for TGF-β signaling. Astragaloside IV also decreased the level of p-SMAD3 and completely blocked its relocation into the nuclei. Conclusion: Astragaloside IV attenuates fibrosis by inhibiting the TGF-β-Smads3 axis in systemic sclerosis." @default.
- W2090844093 created "2016-06-24" @default.
- W2090844093 creator A5011839379 @default.
- W2090844093 creator A5015627976 @default.
- W2090844093 creator A5053131317 @default.
- W2090844093 creator A5074873913 @default.
- W2090844093 creator A5075729955 @default.
- W2090844093 creator A5086684048 @default.
- W2090844093 date "2014-01-01" @default.
- W2090844093 modified "2023-09-27" @default.
- W2090844093 title "Anti-Fibrotic Effects of Astragaloside IV in Systemic Sclerosis" @default.
- W2090844093 cites W1498729963 @default.
- W2090844093 cites W1504410407 @default.
- W2090844093 cites W1599415696 @default.
- W2090844093 cites W1967107405 @default.
- W2090844093 cites W1973111675 @default.
- W2090844093 cites W1978859439 @default.
- W2090844093 cites W1990494547 @default.
- W2090844093 cites W1992213652 @default.
- W2090844093 cites W1998454166 @default.
- W2090844093 cites W2002093513 @default.
- W2090844093 cites W2002854196 @default.
- W2090844093 cites W2009462327 @default.
- W2090844093 cites W2013120577 @default.
- W2090844093 cites W2013358853 @default.
- W2090844093 cites W2015240170 @default.
- W2090844093 cites W2017646616 @default.
- W2090844093 cites W2022701810 @default.
- W2090844093 cites W2022747054 @default.
- W2090844093 cites W2026535970 @default.
- W2090844093 cites W2049942080 @default.
- W2090844093 cites W2053599847 @default.
- W2090844093 cites W2058053333 @default.
- W2090844093 cites W2062089424 @default.
- W2090844093 cites W2066256524 @default.
- W2090844093 cites W2070401522 @default.
- W2090844093 cites W2073067104 @default.
- W2090844093 cites W2081339485 @default.
- W2090844093 cites W2104545078 @default.
- W2090844093 cites W2107008894 @default.
- W2090844093 cites W2133485412 @default.
- W2090844093 cites W2153490433 @default.
- W2090844093 cites W2154601080 @default.
- W2090844093 cites W2155754900 @default.
- W2090844093 cites W2169645723 @default.
- W2090844093 cites W2171966785 @default.
- W2090844093 cites W2351946494 @default.
- W2090844093 cites W2398230196 @default.
- W2090844093 cites W2468878186 @default.
- W2090844093 cites W2600375519 @default.
- W2090844093 doi "https://doi.org/10.1159/000366405" @default.
- W2090844093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25562158" @default.
- W2090844093 hasPublicationYear "2014" @default.
- W2090844093 type Work @default.
- W2090844093 sameAs 2090844093 @default.
- W2090844093 citedByCount "14" @default.
- W2090844093 countsByYear W20908440932015 @default.
- W2090844093 countsByYear W20908440932016 @default.
- W2090844093 countsByYear W20908440932017 @default.
- W2090844093 countsByYear W20908440932019 @default.
- W2090844093 countsByYear W20908440932020 @default.
- W2090844093 countsByYear W20908440932022 @default.
- W2090844093 crossrefType "journal-article" @default.
- W2090844093 hasAuthorship W2090844093A5011839379 @default.
- W2090844093 hasAuthorship W2090844093A5015627976 @default.
- W2090844093 hasAuthorship W2090844093A5053131317 @default.
- W2090844093 hasAuthorship W2090844093A5074873913 @default.
- W2090844093 hasAuthorship W2090844093A5075729955 @default.
- W2090844093 hasAuthorship W2090844093A5086684048 @default.
- W2090844093 hasBestOaLocation W20908440931 @default.
- W2090844093 hasConcept C104317684 @default.
- W2090844093 hasConcept C118131993 @default.
- W2090844093 hasConcept C126322002 @default.
- W2090844093 hasConcept C134018914 @default.
- W2090844093 hasConcept C142724271 @default.
- W2090844093 hasConcept C1491633281 @default.
- W2090844093 hasConcept C150903083 @default.
- W2090844093 hasConcept C185592680 @default.
- W2090844093 hasConcept C202751555 @default.
- W2090844093 hasConcept C207001950 @default.
- W2090844093 hasConcept C25938499 @default.
- W2090844093 hasConcept C2776232574 @default.
- W2090844093 hasConcept C2776415932 @default.
- W2090844093 hasConcept C2776694085 @default.
- W2090844093 hasConcept C2780381497 @default.
- W2090844093 hasConcept C2780559512 @default.
- W2090844093 hasConcept C2781080636 @default.
- W2090844093 hasConcept C55493867 @default.
- W2090844093 hasConcept C71924100 @default.
- W2090844093 hasConcept C86492073 @default.
- W2090844093 hasConcept C86803240 @default.
- W2090844093 hasConcept C98274493 @default.
- W2090844093 hasConceptScore W2090844093C104317684 @default.
- W2090844093 hasConceptScore W2090844093C118131993 @default.
- W2090844093 hasConceptScore W2090844093C126322002 @default.
- W2090844093 hasConceptScore W2090844093C134018914 @default.
- W2090844093 hasConceptScore W2090844093C142724271 @default.
- W2090844093 hasConceptScore W2090844093C1491633281 @default.