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• W2090848164 startingPage "2012" @default.
• W2090848164 abstract "The pharmacokinetics of teicoplanin after single 6-mg/kg intravenous and intraperitoneal doses were studied in five noninfected patients undergoing continuous ambulatory peritoneal dialysis. Biological samples were assayed for teicoplanin content by a microbiological assay technique. Terminal disposition half-life (266.4 +/- 51.9 h [mean +/- standard error of the mean]) was prolonged and total body clearance (0.040 +/- 0.004 ml/min per kg) was reduced compared with values previously reported in subjects with normal renal function. The volume of distribution at steady state (1.15 +/- 0.19 liters/kg) was higher than values previously reported in subjects with normal renal function (0.56 to 0.72 liter/kg). Peritoneal dialysis clearance (0.007 +/- 0.001 ml/min per kg) accounted for only 16.1% of total body clearance. The absolute systemic bioavailability of teicoplanin after intraperitoneal administration was 81.5 +/- 10.7%." @default.
• W2090848164 created "2016-06-24" @default.
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• W2090848164 date "1989-11-01" @default.
• W2090848164 modified "2023-09-27" @default.
• W2090848164 title "Teicoplanin pharmacokinetics in patients undergoing continuous ambulatory peritoneal dialysis after intravenous and intraperitoneal dosing" @default.
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• W2090848164 doi "https://doi.org/10.1128/aac.33.11.2012" @default.
• W2090848164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/172806" @default.
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