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• W2090850845 abstract "The transcription factor WUSCHEL (WUS) acts from a well-defined domain within the Arabidopsis thaliana shoot apical meristem (SAM) to maintain a stem cell niche. A negative-feedback loop involving the CLAVATA (CLV) signaling pathway regulates the number of WUS-expressing cells and provides the current paradigm for the homeostatic maintenance of stem cell numbers. Despite the continual turnover of cells in the SAM during development, the WUS domain remains patterned at a fixed distance below the shoot apex. Recent work has uncovered a positive-feedback loop between WUS function and the plant hormone cytokinin. Furthermore, loss of function of the cytokinin biosynthetic gene, LONELY GUY (LOG), results in a wus-like phenotype in rice. Herein, we find the Arabidopsis LOG4 gene is expressed in the SAM epidermis. We use this to develop a computational model representing a growing SAM to suggest the plausibility that apically derived cytokinin and CLV signaling, together, act as positional cues for patterning the WUS domain within the stem cell niche. Furthermore, model simulations backed by experimental data suggest a previously unknown negative feedback between WUS function and cytokinin biosynthesis in the Arabidopsis SAM epidermis. These results suggest a plausible dynamic feedback principle by which the SAM stem cell niche is patterned." @default.
• W2090850845 created "2016-06-24" @default.
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• W2090850845 date "2012-02-15" @default.
• W2090850845 modified "2023-10-16" @default.
• W2090850845 title "Cytokinin signaling as a positional cue for patterning the apical–basal axis of the growing <i>Arabidopsis</i> shoot meristem" @default.
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• W2090850845 doi "https://doi.org/10.1073/pnas.1200636109" @default.
• W2090850845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3309735" @default.
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