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• W2090851212 abstract "Inflammation is associated with peripheral neuropathy, however the interplay among cytokines, chemokines, and neurons is still unclear. We hypothesized that this neuroinflammatory interaction can be defined by computational modeling based on the dynamics of protein expression in the sciatic nerve of rats subjected to chronic constriction injury. Using Dynamic Bayesian Network inference, we identified interleukin (IL)-18 as a central node associated with neuropathic pain in this animal model. Immunofluorescence supported a role for inflammasome activation and induction of IL-18 at the site of injury. Combined in vivo and in silico approaches may thus highlight novel targets in peripheral neuropathy." @default.
• W2090851212 created "2016-06-24" @default.
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• W2090851212 date "2015-06-01" @default.
• W2090851212 modified "2023-10-17" @default.
• W2090851212 title "In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain" @default.
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• W2090851212 doi "https://doi.org/10.1016/j.jneuroim.2015.04.012" @default.
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