Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090851245> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2090851245 endingPage "348A" @default.
- W2090851245 startingPage "347A" @default.
- W2090851245 abstract "PTCA in the setting of unstable angina (UA) and coronary thrombus (CT) is associated with adverse outcomes. We performed a pilot study of intralesional tPA (20 mg) using an end-hole infusion (Tracker) catheter and intracoronary heparin (5,000 units). delivered over 20 mins, prior to PTCA in 53 pts with UA and CT. Full delivery of tPA and heparin was possible in 47 pts. Activated clotting time was > 300 sec in all pts. PTCA was performed in 48 pts 20 mins after completion of the infusion. Systemic fibrinogenolysis (fibrinogen pre 408 ± 120 mg/dL, post 398 ± 114) and thrombin activation (no increase in fibrinopeptide A or fragment 1.2) did not occur but prolonged clot lysis was evident (D-Dimer pre 196 ± 179 ng/mL, 4 hours post 849 ± 746, P = 0.0001). Angiographic outcomes were (mean ± SD):Empty CellBaselinePost-tPAPost-PTCATIMI Thrombus Scale2.2 ± 1.01.6 ± 1.2**0.5 ± 0.9*MLD by QCA (mm)0.82 ± 0.420.89 ± 0.57***1.90 ± 0.59*TIMI Grade Flow2.6 ± 0.82.5 ± 1.02.9 ± 0.5*p = 0.001**p = 0.007***p = 0.07 (All comparison made with preceding group) p = 0.001 p = 0.007 p = 0.07 (All comparison made with preceding group) PTCA was successful ( < 50% residual stenosis) in 87% and 6% had a major bleeding event. In-hospital outcomes were as follows: death 0, myocardial infarction 4%, abrupt reclosure 11%, repeat PTCA 11%, and CABG 6%. Intralesional tPA with intracoronary heparin causes prolonged thrombolysis without thrombin activation and reduces the extent of coronary thrombus in the setting of unstable angina. It is associated with a high PTCA success rate and favorable in-hospital outcome. Further investigations of this method of local adjunctive thrombolysis and PTCA are warranted." @default.
- W2090851245 created "2016-06-24" @default.
- W2090851245 creator A5012372560 @default.
- W2090851245 creator A5012918602 @default.
- W2090851245 creator A5018002182 @default.
- W2090851245 creator A5019691054 @default.
- W2090851245 creator A5021357839 @default.
- W2090851245 creator A5024035110 @default.
- W2090851245 creator A5031401247 @default.
- W2090851245 creator A5036180000 @default.
- W2090851245 creator A5039990613 @default.
- W2090851245 creator A5040416866 @default.
- W2090851245 creator A5041229626 @default.
- W2090851245 creator A5044787928 @default.
- W2090851245 creator A5045512232 @default.
- W2090851245 creator A5047661952 @default.
- W2090851245 creator A5051200814 @default.
- W2090851245 creator A5060436966 @default.
- W2090851245 creator A5074678695 @default.
- W2090851245 date "1995-02-01" @default.
- W2090851245 modified "2023-10-16" @default.
- W2090851245 title "1001-25 Combined Intralesional Tissue Plasminogen Activator and Intracoronary Heparin in Patients with Unstable Angina and Coronary Thrombus Undergoing PTCA" @default.
- W2090851245 doi "https://doi.org/10.1016/0735-1097(95)92899-g" @default.
- W2090851245 hasPublicationYear "1995" @default.
- W2090851245 type Work @default.
- W2090851245 sameAs 2090851245 @default.
- W2090851245 citedByCount "1" @default.
- W2090851245 crossrefType "journal-article" @default.
- W2090851245 hasAuthorship W2090851245A5012372560 @default.
- W2090851245 hasAuthorship W2090851245A5012918602 @default.
- W2090851245 hasAuthorship W2090851245A5018002182 @default.
- W2090851245 hasAuthorship W2090851245A5019691054 @default.
- W2090851245 hasAuthorship W2090851245A5021357839 @default.
- W2090851245 hasAuthorship W2090851245A5024035110 @default.
- W2090851245 hasAuthorship W2090851245A5031401247 @default.
- W2090851245 hasAuthorship W2090851245A5036180000 @default.
- W2090851245 hasAuthorship W2090851245A5039990613 @default.
- W2090851245 hasAuthorship W2090851245A5040416866 @default.
- W2090851245 hasAuthorship W2090851245A5041229626 @default.
- W2090851245 hasAuthorship W2090851245A5044787928 @default.
- W2090851245 hasAuthorship W2090851245A5045512232 @default.
- W2090851245 hasAuthorship W2090851245A5047661952 @default.
- W2090851245 hasAuthorship W2090851245A5051200814 @default.
- W2090851245 hasAuthorship W2090851245A5060436966 @default.
- W2090851245 hasAuthorship W2090851245A5074678695 @default.
- W2090851245 hasConcept C126322002 @default.
- W2090851245 hasConcept C164705383 @default.
- W2090851245 hasConcept C2777557582 @default.
- W2090851245 hasConcept C2777785093 @default.
- W2090851245 hasConcept C2777987278 @default.
- W2090851245 hasConcept C2777995511 @default.
- W2090851245 hasConcept C2779581417 @default.
- W2090851245 hasConcept C2781362458 @default.
- W2090851245 hasConcept C500558357 @default.
- W2090851245 hasConcept C71924100 @default.
- W2090851245 hasConceptScore W2090851245C126322002 @default.
- W2090851245 hasConceptScore W2090851245C164705383 @default.
- W2090851245 hasConceptScore W2090851245C2777557582 @default.
- W2090851245 hasConceptScore W2090851245C2777785093 @default.
- W2090851245 hasConceptScore W2090851245C2777987278 @default.
- W2090851245 hasConceptScore W2090851245C2777995511 @default.
- W2090851245 hasConceptScore W2090851245C2779581417 @default.
- W2090851245 hasConceptScore W2090851245C2781362458 @default.
- W2090851245 hasConceptScore W2090851245C500558357 @default.
- W2090851245 hasConceptScore W2090851245C71924100 @default.
- W2090851245 hasIssue "2" @default.
- W2090851245 hasLocation W20908512451 @default.
- W2090851245 hasOpenAccess W2090851245 @default.
- W2090851245 hasPrimaryLocation W20908512451 @default.
- W2090851245 hasRelatedWork W1977766748 @default.
- W2090851245 hasRelatedWork W1986689269 @default.
- W2090851245 hasRelatedWork W1988172999 @default.
- W2090851245 hasRelatedWork W2031157079 @default.
- W2090851245 hasRelatedWork W2063187204 @default.
- W2090851245 hasRelatedWork W2073278282 @default.
- W2090851245 hasRelatedWork W2307773399 @default.
- W2090851245 hasRelatedWork W2332320572 @default.
- W2090851245 hasRelatedWork W2885168853 @default.
- W2090851245 hasRelatedWork W2413908167 @default.
- W2090851245 hasVolume "25" @default.
- W2090851245 isParatext "false" @default.
- W2090851245 isRetracted "false" @default.
- W2090851245 magId "2090851245" @default.
- W2090851245 workType "article" @default.