Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090851652> ?p ?o ?g. }
- W2090851652 endingPage "218" @default.
- W2090851652 startingPage "208" @default.
- W2090851652 abstract "Photopolymerized poly(ethylene glycol) (PEG) hydrogels were used as a base platform for the encapsulation and culture of human mesenchymal stem cells (hMSCs). The base PEG formulation presents an environment completely devoid of cell-matrix interactions. As such, viability of hMSCs in unmodified PEG hydrogels is very low. This formulation was modified to contain pendant phosphate groups to facilitate the sequestering of osteopontin within the gel, as well as pendant cell-adhesive RGD peptide sequences, which are found in osteopontin and other cell adhesion proteins. The survivability of hMSCs was examined with culture time and as a function of the gel chemistry to examine the role of cell-matrix interactions in promoting long-term viability. In the absence of any adhesive ligands, hMSC viability drops to 15% after 1 week in culture. However, by incorporating the RGD sequence or pendant phosphate groups this low viability was rescued to 75% and 97%, respectively. It is believed that the phosphate groups promote mineralization of the hydrogel network, and this mineral phase sequesters cell-secreted osteopontin, resulting in enhanced cell-matrix interactions and improved cell viability." @default.
- W2090851652 created "2016-06-24" @default.
- W2090851652 creator A5037165431 @default.
- W2090851652 creator A5076013704 @default.
- W2090851652 creator A5089403281 @default.
- W2090851652 date "2005-05-01" @default.
- W2090851652 modified "2023-10-14" @default.
- W2090851652 title "Synthetic hydrogel niches that promote hMSC viability" @default.
- W2090851652 cites W185026779 @default.
- W2090851652 cites W1968421500 @default.
- W2090851652 cites W1977947034 @default.
- W2090851652 cites W1980225254 @default.
- W2090851652 cites W1980873308 @default.
- W2090851652 cites W1981393628 @default.
- W2090851652 cites W1983072511 @default.
- W2090851652 cites W1984413372 @default.
- W2090851652 cites W1991972695 @default.
- W2090851652 cites W1999277351 @default.
- W2090851652 cites W2001337966 @default.
- W2090851652 cites W2008021821 @default.
- W2090851652 cites W2009734421 @default.
- W2090851652 cites W2012771572 @default.
- W2090851652 cites W2014673628 @default.
- W2090851652 cites W2015203259 @default.
- W2090851652 cites W2020136363 @default.
- W2090851652 cites W2024621576 @default.
- W2090851652 cites W2029815826 @default.
- W2090851652 cites W2034951155 @default.
- W2090851652 cites W2035572879 @default.
- W2090851652 cites W2036954174 @default.
- W2090851652 cites W2037936753 @default.
- W2090851652 cites W2042217942 @default.
- W2090851652 cites W2043669923 @default.
- W2090851652 cites W2050911192 @default.
- W2090851652 cites W2051920559 @default.
- W2090851652 cites W2068135722 @default.
- W2090851652 cites W2068969716 @default.
- W2090851652 cites W2070050615 @default.
- W2090851652 cites W2072261072 @default.
- W2090851652 cites W2074183516 @default.
- W2090851652 cites W2080205733 @default.
- W2090851652 cites W2081789842 @default.
- W2090851652 cites W2093197537 @default.
- W2090851652 cites W2102469132 @default.
- W2090851652 cites W2103015540 @default.
- W2090851652 cites W2114286636 @default.
- W2090851652 cites W2124559417 @default.
- W2090851652 cites W2126424577 @default.
- W2090851652 cites W2130985015 @default.
- W2090851652 cites W2144268541 @default.
- W2090851652 cites W2159999899 @default.
- W2090851652 cites W2164880987 @default.
- W2090851652 cites W2222872518 @default.
- W2090851652 cites W2257324588 @default.
- W2090851652 doi "https://doi.org/10.1016/j.matbio.2005.03.004" @default.
- W2090851652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15896949" @default.
- W2090851652 hasPublicationYear "2005" @default.
- W2090851652 type Work @default.
- W2090851652 sameAs 2090851652 @default.
- W2090851652 citedByCount "315" @default.
- W2090851652 countsByYear W20908516522012 @default.
- W2090851652 countsByYear W20908516522013 @default.
- W2090851652 countsByYear W20908516522014 @default.
- W2090851652 countsByYear W20908516522015 @default.
- W2090851652 countsByYear W20908516522016 @default.
- W2090851652 countsByYear W20908516522017 @default.
- W2090851652 countsByYear W20908516522018 @default.
- W2090851652 countsByYear W20908516522019 @default.
- W2090851652 countsByYear W20908516522020 @default.
- W2090851652 countsByYear W20908516522021 @default.
- W2090851652 countsByYear W20908516522022 @default.
- W2090851652 countsByYear W20908516522023 @default.
- W2090851652 crossrefType "journal-article" @default.
- W2090851652 hasAuthorship W2090851652A5037165431 @default.
- W2090851652 hasAuthorship W2090851652A5076013704 @default.
- W2090851652 hasAuthorship W2090851652A5089403281 @default.
- W2090851652 hasConcept C10138342 @default.
- W2090851652 hasConcept C108586683 @default.
- W2090851652 hasConcept C12554922 @default.
- W2090851652 hasConcept C1491633281 @default.
- W2090851652 hasConcept C162324750 @default.
- W2090851652 hasConcept C178790620 @default.
- W2090851652 hasConcept C185592680 @default.
- W2090851652 hasConcept C188027245 @default.
- W2090851652 hasConcept C198826908 @default.
- W2090851652 hasConcept C203014093 @default.
- W2090851652 hasConcept C2777516009 @default.
- W2090851652 hasConcept C2780804394 @default.
- W2090851652 hasConcept C53227056 @default.
- W2090851652 hasConcept C54355233 @default.
- W2090851652 hasConcept C54400483 @default.
- W2090851652 hasConcept C55493867 @default.
- W2090851652 hasConcept C81885089 @default.
- W2090851652 hasConcept C86803240 @default.
- W2090851652 hasConcept C95444343 @default.
- W2090851652 hasConceptScore W2090851652C10138342 @default.
- W2090851652 hasConceptScore W2090851652C108586683 @default.
- W2090851652 hasConceptScore W2090851652C12554922 @default.