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- W2090852651 abstract "Binding assays are increasingly used as a screening method for protein kinase inhibitors; however, as yet only a weak correlation with enzymatic activity-based assays has been demonstrated. We show that the correlation between the two types of assays can be improved using more precise screening conditions. Furthermore a marked improvement in the correlation was found by using kinase constructs containing the catalytic domain in presence of additional domains or subunits." @default.
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- W2090852651 date "2014-06-10" @default.
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- W2090852651 title "A Comparison of Protein Kinases Inhibitor Screening Methods Using Both Enzymatic Activity and Binding Affinity Determination" @default.
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- W2090852651 doi "https://doi.org/10.1371/journal.pone.0098800" @default.
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