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• W2090853471 abstract "The 2,4-diacyl paclitaxel analogues 8a-8r were prepared from paclitaxel by acylation of 4-deacetyl-2-debenzoylpaclitaxel 1,2-carbonate (3) followed either by hydrolysis of the carbonate and acylation or by direct treatment of the carbonate with an aryllithium. Some of the resulting derivatives showed significantly improved tubulin assembly activity and cytotoxicity as compared with paclitaxel; in some cases this improvement was especially significant for paclitaxel-resistant cell lines." @default.
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• W2090853471 date "2001-01-01" @default.
• W2090853471 modified "2023-09-29" @default.
• W2090853471 title "Synthesis and bioactivity of 2,4-diacyl analogues of paclitaxel" @default.
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• W2090853471 doi "https://doi.org/10.1016/s0968-0896(00)00233-9" @default.
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