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- W2090855103 abstract "The treatment of rhabdomyosarcoma (RMS) is challenging, and the prognosis remains especially poor for high-grade RMS with metastasis. The conventional treatment of RMS is based on multi-agent chemotherapy combined with resection and radiotherapy, which are often marked by low success rate. Alternative therapeutic options include the combination of standard treatments with immunotherapy. We generated a microtubule-associated protein (MAP)-based fully human cytolytic fusion protein (hCFP) targeting the fetal acetylcholine receptor, which is expressed on RMS cells. We were able to express and purify functional scFv35-MAP from Escherichia coli cells. Moreover, we found that scFv35-MAP is rapidly internalized by target cells after binding its receptor, and exhibits specific cytotoxicity toward FL-OH1 and RD cells in vitro. We also confirmed that scFv35-MAP induces apoptosis in FL-OH1 and RD cells. The in vivo potential of scFv35-MAP will need to be considered in further studies." @default.
- W2090855103 created "2016-06-24" @default.
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- W2090855103 date "2015-09-01" @default.
- W2090855103 modified "2023-09-28" @default.
- W2090855103 title "Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein" @default.
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- W2090855103 doi "https://doi.org/10.1016/j.canlet.2015.04.004" @default.
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