FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090863707> ?p ?o ?g. }

• W2090863707 endingPage "1969" @default.
• W2090863707 startingPage "1964" @default.
• W2090863707 abstract "Modern drug discovery often involves screening small molecules for their ability to bind to a preselected protein target. Target-oriented syntheses of these small molecules, individually or as collections (focused libraries), can be planned effectively with retrosynthetic analysis. Drug discovery can also involve screening small molecules for their ability to modulate a biological pathway in cells or organisms, without regard for any particular protein target. This process is likely to benefit in the future from an evolving forward analysis of synthetic pathways, used in diversity-oriented synthesis, that leads to structurally complex and diverse small molecules. One goal of diversity-oriented syntheses is to synthesize efficiently a collection of small molecules capable of perturbing any disease-related biological pathway, leading eventually to the identification of therapeutic protein targets capable of being modulated by small molecules. Several synthetic planning principles for diversity-oriented synthesis and their role in the drug discovery process are presented in this review." @default.
• W2090863707 created "2016-06-24" @default.
• W2090863707 creator A5035618234 @default.
• W2090863707 date "2000-03-17" @default.
• W2090863707 modified "2023-10-18" @default.
• W2090863707 title "Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery" @default.
• W2090863707 cites W1968045510 @default.
• W2090863707 cites W1979187723 @default.
• W2090863707 cites W1980441363 @default.
• W2090863707 cites W1981488709 @default.
• W2090863707 cites W1990728523 @default.
• W2090863707 cites W2006446936 @default.
• W2090863707 cites W2022073579 @default.
• W2090863707 cites W2025690482 @default.
• W2090863707 cites W2028983179 @default.
• W2090863707 cites W2029178312 @default.
• W2090863707 cites W2039492060 @default.
• W2090863707 cites W2040815941 @default.
• W2090863707 cites W2041719513 @default.
• W2090863707 cites W2045240205 @default.
• W2090863707 cites W2056748810 @default.
• W2090863707 cites W2059914290 @default.
• W2090863707 cites W2060618478 @default.
• W2090863707 cites W2061894301 @default.
• W2090863707 cites W2065672888 @default.
• W2090863707 cites W2070865589 @default.
• W2090863707 cites W2070937799 @default.
• W2090863707 cites W2073258117 @default.
• W2090863707 cites W2078914787 @default.
• W2090863707 cites W2094850820 @default.
• W2090863707 cites W2094954825 @default.
• W2090863707 cites W2099928393 @default.
• W2090863707 cites W2142759234 @default.
• W2090863707 cites W2149464124 @default.
• W2090863707 cites W2171386360 @default.
• W2090863707 cites W2320556745 @default.
• W2090863707 cites W2916451683 @default.
• W2090863707 cites W2949650697 @default.
• W2090863707 cites W2950469730 @default.
• W2090863707 cites W2951395127 @default.
• W2090863707 cites W2952939591 @default.
• W2090863707 doi "https://doi.org/10.1126/science.287.5460.1964" @default.
• W2090863707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10720315" @default.
• W2090863707 hasPublicationYear "2000" @default.
• W2090863707 type Work @default.
• W2090863707 sameAs 2090863707 @default.
• W2090863707 citedByCount "2235" @default.
• W2090863707 countsByYear W20908637072012 @default.
• W2090863707 countsByYear W20908637072013 @default.
• W2090863707 countsByYear W20908637072014 @default.
• W2090863707 countsByYear W20908637072015 @default.
• W2090863707 countsByYear W20908637072016 @default.
• W2090863707 countsByYear W20908637072017 @default.
• W2090863707 countsByYear W20908637072018 @default.
• W2090863707 countsByYear W20908637072019 @default.
• W2090863707 countsByYear W20908637072020 @default.
• W2090863707 countsByYear W20908637072021 @default.
• W2090863707 countsByYear W20908637072022 @default.
• W2090863707 countsByYear W20908637072023 @default.
• W2090863707 crossrefType "journal-article" @default.
• W2090863707 hasAuthorship W2090863707A5035618234 @default.
• W2090863707 hasConcept C116834253 @default.
• W2090863707 hasConcept C144024400 @default.
• W2090863707 hasConcept C161624437 @default.
• W2090863707 hasConcept C171250308 @default.
• W2090863707 hasConcept C185592680 @default.
• W2090863707 hasConcept C18903297 @default.
• W2090863707 hasConcept C19165224 @default.
• W2090863707 hasConcept C192562407 @default.
• W2090863707 hasConcept C21951064 @default.
• W2090863707 hasConcept C2781316041 @default.
• W2090863707 hasConcept C35753019 @default.
• W2090863707 hasConcept C42437451 @default.
• W2090863707 hasConcept C55493867 @default.
• W2090863707 hasConcept C60644358 @default.
• W2090863707 hasConcept C70721500 @default.
• W2090863707 hasConcept C71240020 @default.
• W2090863707 hasConcept C74187038 @default.
• W2090863707 hasConcept C86803240 @default.
• W2090863707 hasConceptScore W2090863707C116834253 @default.
• W2090863707 hasConceptScore W2090863707C144024400 @default.
• W2090863707 hasConceptScore W2090863707C161624437 @default.
• W2090863707 hasConceptScore W2090863707C171250308 @default.
• W2090863707 hasConceptScore W2090863707C185592680 @default.
• W2090863707 hasConceptScore W2090863707C18903297 @default.
• W2090863707 hasConceptScore W2090863707C19165224 @default.
• W2090863707 hasConceptScore W2090863707C192562407 @default.
• W2090863707 hasConceptScore W2090863707C21951064 @default.
• W2090863707 hasConceptScore W2090863707C2781316041 @default.
• W2090863707 hasConceptScore W2090863707C35753019 @default.
• W2090863707 hasConceptScore W2090863707C42437451 @default.
• W2090863707 hasConceptScore W2090863707C55493867 @default.
• W2090863707 hasConceptScore W2090863707C60644358 @default.
• W2090863707 hasConceptScore W2090863707C70721500 @default.
• W2090863707 hasConceptScore W2090863707C71240020 @default.
• W2090863707 hasConceptScore W2090863707C74187038 @default.
• W2090863707 hasConceptScore W2090863707C86803240 @default.
• W2090863707 hasIssue "5460" @default.

• next