Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090865197> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2090865197 endingPage "294" @default.
- W2090865197 startingPage "289" @default.
- W2090865197 abstract "The thiazolidinedione derivative CGP 19984 has previously been shown to suppress the growth of hormone-dependent mammary and prostatic tumors, primarily by reducing gonadotropin and subsequently gonadal steroid secretion. The present study examines the effects of CGP 19984 on the growth and hormone secretion of the autonomous, but estrogen-responsive, MtT-W10 mammosomatotropic transplantable rat pituitary tumor. Intact tumor-bearing Wistar/Furth female rats were administered vehicle or 25, 100, or 250 mg/ kg CGP 19984 p. o. 5 × week for 4 weeks. CGP 19984 was found to significantly reduce MtT-W 10 tumor growth and weight and reduce prolactin and growth hormone (GH) secretion in a dose-responsive manner. A similar study in ovariectomized rats also showed that CGP 19984 treatment suppressed MtT-W 10 pituitary tumor growth, weight and hormone secretion in a dose-responsive manner, suggesting a direct inhibitory action of this drug on the tumor. In a third study, bromocryptine (CB-154; 5 mg/kg) and CGP 19984 (50 mg/kg) were both found to be effective in suppressing growth of the MtT-W 10 tumor in intact female rats. However, rats treated with CGP 19984 alone had reduced serum and tumor GH and prolactin concentrations, while rats treated with CB- 154 alone had reduced serum and tumor prolactin, but no change in GH concentrations. These results suggest that CGP 19984 effectively inhibits growth and hormone secretion of the autonomous MtT-W 10 pituitary tumor by apparently suppressing both somatotropic and lactotropic cell populations within the tumor. Furthermore, these findings indicate that CGP 19984 may be an effective alternative to CB-154 in the clinical treatment of prolactin-producing adenomas, as well as other types of pituitary adenomas." @default.
- W2090865197 created "2016-06-24" @default.
- W2090865197 creator A5010973711 @default.
- W2090865197 creator A5052063796 @default.
- W2090865197 creator A5061101570 @default.
- W2090865197 date "1988-08-15" @default.
- W2090865197 modified "2023-09-24" @default.
- W2090865197 title "Effects of the thiazolidinedione derivative CGP 19984 on growth and endocrine function of the Mtt-W10 transplantable mammosmatotoropic pituitary tumor in female rats" @default.
- W2090865197 cites W1521287845 @default.
- W2090865197 cites W1968644747 @default.
- W2090865197 cites W2018495851 @default.
- W2090865197 cites W2019744734 @default.
- W2090865197 cites W2035497531 @default.
- W2090865197 cites W2037388684 @default.
- W2090865197 cites W2049162449 @default.
- W2090865197 cites W2081972040 @default.
- W2090865197 cites W2082465748 @default.
- W2090865197 cites W2088735547 @default.
- W2090865197 cites W2090760014 @default.
- W2090865197 cites W2097313178 @default.
- W2090865197 cites W4244196365 @default.
- W2090865197 doi "https://doi.org/10.1002/ijc.2910420225" @default.
- W2090865197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3403072" @default.
- W2090865197 hasPublicationYear "1988" @default.
- W2090865197 type Work @default.
- W2090865197 sameAs 2090865197 @default.
- W2090865197 citedByCount "1" @default.
- W2090865197 crossrefType "journal-article" @default.
- W2090865197 hasAuthorship W2090865197A5010973711 @default.
- W2090865197 hasAuthorship W2090865197A5052063796 @default.
- W2090865197 hasAuthorship W2090865197A5061101570 @default.
- W2090865197 hasConcept C121608353 @default.
- W2090865197 hasConcept C126322002 @default.
- W2090865197 hasConcept C134018914 @default.
- W2090865197 hasConcept C2776187077 @default.
- W2090865197 hasConcept C2777164284 @default.
- W2090865197 hasConcept C2777658017 @default.
- W2090865197 hasConcept C2779064019 @default.
- W2090865197 hasConcept C2780783641 @default.
- W2090865197 hasConcept C2781449511 @default.
- W2090865197 hasConcept C2908910360 @default.
- W2090865197 hasConcept C49039625 @default.
- W2090865197 hasConcept C530470458 @default.
- W2090865197 hasConcept C54799321 @default.
- W2090865197 hasConcept C55493867 @default.
- W2090865197 hasConcept C62112901 @default.
- W2090865197 hasConcept C71315377 @default.
- W2090865197 hasConcept C71924100 @default.
- W2090865197 hasConcept C8264082 @default.
- W2090865197 hasConcept C86803240 @default.
- W2090865197 hasConcept C94984642 @default.
- W2090865197 hasConceptScore W2090865197C121608353 @default.
- W2090865197 hasConceptScore W2090865197C126322002 @default.
- W2090865197 hasConceptScore W2090865197C134018914 @default.
- W2090865197 hasConceptScore W2090865197C2776187077 @default.
- W2090865197 hasConceptScore W2090865197C2777164284 @default.
- W2090865197 hasConceptScore W2090865197C2777658017 @default.
- W2090865197 hasConceptScore W2090865197C2779064019 @default.
- W2090865197 hasConceptScore W2090865197C2780783641 @default.
- W2090865197 hasConceptScore W2090865197C2781449511 @default.
- W2090865197 hasConceptScore W2090865197C2908910360 @default.
- W2090865197 hasConceptScore W2090865197C49039625 @default.
- W2090865197 hasConceptScore W2090865197C530470458 @default.
- W2090865197 hasConceptScore W2090865197C54799321 @default.
- W2090865197 hasConceptScore W2090865197C55493867 @default.
- W2090865197 hasConceptScore W2090865197C62112901 @default.
- W2090865197 hasConceptScore W2090865197C71315377 @default.
- W2090865197 hasConceptScore W2090865197C71924100 @default.
- W2090865197 hasConceptScore W2090865197C8264082 @default.
- W2090865197 hasConceptScore W2090865197C86803240 @default.
- W2090865197 hasConceptScore W2090865197C94984642 @default.
- W2090865197 hasIssue "2" @default.
- W2090865197 hasLocation W20908651971 @default.
- W2090865197 hasLocation W20908651972 @default.
- W2090865197 hasOpenAccess W2090865197 @default.
- W2090865197 hasPrimaryLocation W20908651971 @default.
- W2090865197 hasRelatedWork W1966296538 @default.
- W2090865197 hasRelatedWork W2003455196 @default.
- W2090865197 hasRelatedWork W2068781432 @default.
- W2090865197 hasRelatedWork W2076637066 @default.
- W2090865197 hasRelatedWork W2080367469 @default.
- W2090865197 hasRelatedWork W2087956231 @default.
- W2090865197 hasRelatedWork W2090865197 @default.
- W2090865197 hasRelatedWork W2108578925 @default.
- W2090865197 hasRelatedWork W2109773872 @default.
- W2090865197 hasRelatedWork W2152306407 @default.
- W2090865197 hasVolume "42" @default.
- W2090865197 isParatext "false" @default.
- W2090865197 isRetracted "false" @default.
- W2090865197 magId "2090865197" @default.
- W2090865197 workType "article" @default.