FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090868225> ?p ?o ?g. }

• W2090868225 endingPage "e77358" @default.
• W2090868225 startingPage "e77358" @default.
• W2090868225 abstract "Helicobacter pylori infection has been proposed to be associated with various diseases of the hepatobiliary tract, including cancer of the bile duct epithelial cells (cholangiocarcinoma, CCA). The ability of H. pylori bacteria to cause pathogenic effects in these cells has, however, yet to be investigated. Given that the cag pathogenicity island (cagPAI) is required for H. pylori pathogenesis in gastric epithelial cells, we investigated wild-type and cag mutant strains for their ability to adhere, be internalized and induce pro-inflammatory responses in two bile duct epithelial cell lines derived from cases of CCA. The findings from these experiments were compared to results obtained with the well-characterized AGS gastric cancer cell line. We showed that the cagPAI encodes factors involved in H. pylori internalization in CCA cells, but not for adhesion to these cells. Consistent with previous studies in hepatocytes, actin polymerization and α5β1 integrin may be involved in H. pylori internalization in CCA cells. As for AGS cells, we observed significantly reduced levels of NF-κB activation and IL-8 production in CCA cells stimulated with either cagA, cagL or cagPAI bacteria, when compared with wild-type bacteria. Importantly, these IL-8 responses could be inhibited via either pre-treatment of cells with antibodies to α5β1 integrins, or via siRNA-mediated knockdown of the innate immune signaling molecules, nucleotide oligomerization domain 1 (NOD1) and myeloid differentiation response gene 88 (MyD88). Taken together, the data demonstrate that the cagPAI is critical for H. pylori pathogenesis in bile duct cells, thus providing a potential causal link for H. pylori in biliary tract disease." @default.
• W2090868225 created "2016-06-24" @default.
• W2090868225 creator A5011390932 @default.
• W2090868225 creator A5037244623 @default.
• W2090868225 creator A5041543030 @default.
• W2090868225 creator A5063798542 @default.
• W2090868225 creator A5068619753 @default.
• W2090868225 creator A5070150158 @default.
• W2090868225 date "2013-10-15" @default.
• W2090868225 modified "2023-09-25" @default.
• W2090868225 title "Helicobacter pylori cag Pathogenicity Island (cagPAI) Involved in Bacterial Internalization and IL-8 Induced Responses via NOD1- and MyD88-Dependent Mechanisms in Human Biliary Epithelial Cells" @default.
• W2090868225 cites W1480166846 @default.
• W2090868225 cites W1533711237 @default.
• W2090868225 cites W162157620 @default.
• W2090868225 cites W1964433907 @default.
• W2090868225 cites W1964488322 @default.
• W2090868225 cites W1965254865 @default.
• W2090868225 cites W1965323568 @default.
• W2090868225 cites W1973232347 @default.
• W2090868225 cites W1974847581 @default.
• W2090868225 cites W1979736739 @default.
• W2090868225 cites W1984472672 @default.
• W2090868225 cites W1991001128 @default.
• W2090868225 cites W1993428261 @default.
• W2090868225 cites W1994942139 @default.
• W2090868225 cites W1995785411 @default.
• W2090868225 cites W2002762908 @default.
• W2090868225 cites W2003035812 @default.
• W2090868225 cites W2003731069 @default.
• W2090868225 cites W2005078546 @default.
• W2090868225 cites W2009831757 @default.
• W2090868225 cites W2010238923 @default.
• W2090868225 cites W2012369608 @default.
• W2090868225 cites W2014026686 @default.
• W2090868225 cites W2020861520 @default.
• W2090868225 cites W2027770415 @default.
• W2090868225 cites W2029231027 @default.
• W2090868225 cites W2029767217 @default.
• W2090868225 cites W2031217847 @default.
• W2090868225 cites W2031834188 @default.
• W2090868225 cites W2033051264 @default.
• W2090868225 cites W2037200031 @default.
• W2090868225 cites W2040853949 @default.
• W2090868225 cites W2046454404 @default.
• W2090868225 cites W2046532414 @default.
• W2090868225 cites W2065645776 @default.
• W2090868225 cites W2067832126 @default.
• W2090868225 cites W2072523791 @default.
• W2090868225 cites W2082807937 @default.
• W2090868225 cites W2092957678 @default.
• W2090868225 cites W2103192720 @default.
• W2090868225 cites W2108467352 @default.
• W2090868225 cites W2121075772 @default.
• W2090868225 cites W2131208401 @default.
• W2090868225 cites W2134023585 @default.
• W2090868225 cites W2135868208 @default.
• W2090868225 cites W2136143589 @default.
• W2090868225 cites W2147025591 @default.
• W2090868225 cites W2149980799 @default.
• W2090868225 cites W2168112559 @default.
• W2090868225 cites W4313342441 @default.
• W2090868225 doi "https://doi.org/10.1371/journal.pone.0077358" @default.
• W2090868225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3797076" @default.
• W2090868225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24143223" @default.
• W2090868225 hasPublicationYear "2013" @default.
• W2090868225 type Work @default.
• W2090868225 sameAs 2090868225 @default.
• W2090868225 citedByCount "38" @default.
• W2090868225 countsByYear W20908682252014 @default.
• W2090868225 countsByYear W20908682252015 @default.
• W2090868225 countsByYear W20908682252016 @default.
• W2090868225 countsByYear W20908682252017 @default.
• W2090868225 countsByYear W20908682252018 @default.
• W2090868225 countsByYear W20908682252019 @default.
• W2090868225 countsByYear W20908682252020 @default.
• W2090868225 countsByYear W20908682252021 @default.
• W2090868225 countsByYear W20908682252022 @default.
• W2090868225 countsByYear W20908682252023 @default.
• W2090868225 crossrefType "journal-article" @default.
• W2090868225 hasAuthorship W2090868225A5011390932 @default.
• W2090868225 hasAuthorship W2090868225A5037244623 @default.
• W2090868225 hasAuthorship W2090868225A5041543030 @default.
• W2090868225 hasAuthorship W2090868225A5063798542 @default.
• W2090868225 hasAuthorship W2090868225A5068619753 @default.
• W2090868225 hasAuthorship W2090868225A5070150158 @default.
• W2090868225 hasBestOaLocation W20908682251 @default.
• W2090868225 hasConcept C104317684 @default.
• W2090868225 hasConcept C136449434 @default.
• W2090868225 hasConcept C139770010 @default.
• W2090868225 hasConcept C1491633281 @default.
• W2090868225 hasConcept C203014093 @default.
• W2090868225 hasConcept C2776409635 @default.
• W2090868225 hasConcept C2778204961 @default.
• W2090868225 hasConcept C2781065037 @default.
• W2090868225 hasConcept C523546767 @default.
• W2090868225 hasConcept C54355233 @default.
• W2090868225 hasConcept C55493867 @default.
• W2090868225 hasConcept C60987743 @default.

• next