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• W2090869819 abstract "The three clostridial cytotoxins, i.e. α-toxin of C. novyi (Toxα-nov), toxin B of C. difficile (ToxB-dif) and lethal toxin of C. sordellii (LT-sor) consist of single peptide chains of about 200,000 (Toxα-nov), 250,000 (LT-sor) and 275,000 (ToxB-dif) mol. wts. ToxB-dif and LT-sor but not Toxα-nov cross-reacted with rabbit polyclonal antibodies. Toxicity upon i.v. injection in mice was similar (ld50, 100 hr, 50–200 ng/kg) and was characterized by a slowly developing fluid loss into the interstitial space. When injected into the rat paw the toxins caused a delayed local edema lasting for days. In vitro the three toxins provoked a persistent retraction of endothelial cells cultured from pig pulmonary artery. ToxB-dif and Toxα-nov triggered the accumulation of F-actin in the perinuclear region at the expense of the tight peripheral bands whereas LT-sor led to a random loss of microfilament structure. The toxins inhibited uridine incorporation into endothelial or chicken embryonic cells whereas T 84 cells responded by an about 10-fold increase of uridine incorporation. Neither toxin ADP-ribosylated actin. The similarities between the three cytotoxins warrant their arrangement into a common group which perturbs the microfilament system." @default.
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• W2090869819 date "1991-01-01" @default.
• W2090869819 modified "2023-10-01" @default.
• W2090869819 title "A comparative biochemical, pharmacological and immunological study of Clostridium novyi α-toxin, C. difficile toxin B and C. sordellii lethal toxin" @default.
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• W2090869819 doi "https://doi.org/10.1016/0041-0101(91)90224-f" @default.
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