Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090869890> ?p ?o ?g. }
- W2090869890 endingPage "421" @default.
- W2090869890 startingPage "408" @default.
- W2090869890 abstract "In preclinical studies screening for novel antidepressants, male and female animals should be used. However, in a widely used antidepressant test, the forced swim test (FST), sex differences between males and females are not consistent. These discrepancies may discourage the inclusion of females in FST studies. In order to overcome this problem and provide a detailed insight regarding the use of female animals in the FST, we designed the following experiment and we performed a thorough analysis of the relevant literature. Male and female Wistar adult rats were subjected to the FST and sertraline was used as an antidepressant in two doses (10 mg/kg and 40 mg/kg, 3 injections in 24 h). Rodents were subjected in the two FST sessions during all possible combinations of the estrous cycle stages. We found that females exhibited higher levels of immobility than males and this sex difference was alleviated following antidepressant treatment. Sertraline at both doses enhanced swimming in both sexes, but females appeared more responsive to lower sertraline doses regarding immobility levels. Surprisingly, the high sertraline dose enhanced climbing particularly in proestrous and diestrous. Marked sex differences were also observed in the frequency of head swinging, with females exhibiting lower counts than males. Conclusively, when screening for new antidepressants, it is recommended to use standard FST procedures and if possible to include females in all phases of the cycle. Using only one dose of an investigational drug in females in certain phases of the cycle could result to false negative results." @default.
- W2090869890 created "2016-06-24" @default.
- W2090869890 creator A5031814341 @default.
- W2090869890 creator A5038698065 @default.
- W2090869890 creator A5041548462 @default.
- W2090869890 creator A5055129798 @default.
- W2090869890 creator A5062188933 @default.
- W2090869890 creator A5081025298 @default.
- W2090869890 date "2015-12-01" @default.
- W2090869890 modified "2023-10-14" @default.
- W2090869890 title "Forced swim test: What about females?" @default.
- W2090869890 cites W1501937832 @default.
- W2090869890 cites W1558137567 @default.
- W2090869890 cites W1963905580 @default.
- W2090869890 cites W1964114510 @default.
- W2090869890 cites W1965661602 @default.
- W2090869890 cites W1968169940 @default.
- W2090869890 cites W1971157478 @default.
- W2090869890 cites W1971510748 @default.
- W2090869890 cites W1972049578 @default.
- W2090869890 cites W1972849193 @default.
- W2090869890 cites W1973400965 @default.
- W2090869890 cites W1975252975 @default.
- W2090869890 cites W1977205678 @default.
- W2090869890 cites W1977670014 @default.
- W2090869890 cites W1978926207 @default.
- W2090869890 cites W1979025693 @default.
- W2090869890 cites W1979420282 @default.
- W2090869890 cites W1984710968 @default.
- W2090869890 cites W1986646552 @default.
- W2090869890 cites W1987566523 @default.
- W2090869890 cites W1987990233 @default.
- W2090869890 cites W1988279428 @default.
- W2090869890 cites W1991780644 @default.
- W2090869890 cites W1992255304 @default.
- W2090869890 cites W1994181492 @default.
- W2090869890 cites W1994391072 @default.
- W2090869890 cites W1995318031 @default.
- W2090869890 cites W1995465899 @default.
- W2090869890 cites W1997959752 @default.
- W2090869890 cites W1998893802 @default.
- W2090869890 cites W2000362647 @default.
- W2090869890 cites W2003897770 @default.
- W2090869890 cites W2005128569 @default.
- W2090869890 cites W2005270780 @default.
- W2090869890 cites W2005828107 @default.
- W2090869890 cites W2006000660 @default.
- W2090869890 cites W2008255682 @default.
- W2090869890 cites W2009792683 @default.
- W2090869890 cites W2010537971 @default.
- W2090869890 cites W2010869612 @default.
- W2090869890 cites W2012622060 @default.
- W2090869890 cites W2013484791 @default.
- W2090869890 cites W2013598219 @default.
- W2090869890 cites W2017201333 @default.
- W2090869890 cites W2018813517 @default.
- W2090869890 cites W2023753446 @default.
- W2090869890 cites W2024240021 @default.
- W2090869890 cites W2024376065 @default.
- W2090869890 cites W2024551842 @default.
- W2090869890 cites W2026081258 @default.
- W2090869890 cites W2026702399 @default.
- W2090869890 cites W2027431314 @default.
- W2090869890 cites W2027915727 @default.
- W2090869890 cites W2030804316 @default.
- W2090869890 cites W2032009827 @default.
- W2090869890 cites W2032168782 @default.
- W2090869890 cites W2034189826 @default.
- W2090869890 cites W2034877248 @default.
- W2090869890 cites W2035121631 @default.
- W2090869890 cites W2035812012 @default.
- W2090869890 cites W2036852450 @default.
- W2090869890 cites W2037276809 @default.
- W2090869890 cites W2038562311 @default.
- W2090869890 cites W2038805623 @default.
- W2090869890 cites W2041849031 @default.
- W2090869890 cites W2044069216 @default.
- W2090869890 cites W2046434060 @default.
- W2090869890 cites W2047086130 @default.
- W2090869890 cites W2052312283 @default.
- W2090869890 cites W2054179832 @default.
- W2090869890 cites W2056104468 @default.
- W2090869890 cites W2056439165 @default.
- W2090869890 cites W2056826652 @default.
- W2090869890 cites W2057200138 @default.
- W2090869890 cites W2061014586 @default.
- W2090869890 cites W2061200619 @default.
- W2090869890 cites W2061367121 @default.
- W2090869890 cites W2066650091 @default.
- W2090869890 cites W2067165484 @default.
- W2090869890 cites W2068248612 @default.
- W2090869890 cites W2069011223 @default.
- W2090869890 cites W2069937474 @default.
- W2090869890 cites W2070385784 @default.
- W2090869890 cites W2071000148 @default.
- W2090869890 cites W2072858297 @default.
- W2090869890 cites W2076444609 @default.
- W2090869890 cites W2078826561 @default.