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• W2090871210 startingPage "4818" @default.
• W2090871210 abstract "Interleukin-1 beta is believed to contribute to the pathophysiology of rheumatoid arthritis by activating collagenase gene expression. We have used a cell culture model of rabbit synovial fibroblasts to examine the molecular mechanisms of IL-1 beta-mediated collagenase gene expression. Stimulation of rabbit synovial fibroblasts with 10 ng/ml recombinant human IL-1 beta resulted in a 20-fold increase in collagenase mRNA by 12 h. Transient transfection studies using collagenase promoter-CAT constructs demonstrated that proximal sequences responded poorly to IL-1 beta, possibly due to insufficient activation of AP-1 by this cytokine. More distal sequences were required for IL-1 beta responsiveness, with a 4700 bp construct showing approximately 5-fold induction above control. To examine post-transcriptional mechanisms, transcript from a human collagenase cDNA was constitutively produced by the simian virus 40 early promoter. IL-1 beta stabilized the constitutively expressed human transcript. Furthermore, mutation of the ATTTA motifs in the 3' untranslated region of the human gene also stabilized the transcript. Finally, the rabbit collagenase 3' untranslated region destabilized a constitutively transcribed chloramphenicol acetyltransferase transcript. These data indicate that in addition to activating transcription, IL-1 beta increases collagenase transcript stability by reversing the destabilizing effects of sequences in the 3' untranslated region." @default.
• W2090871210 created "2016-06-24" @default.
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• W2090871210 date "1994-01-01" @default.
• W2090871210 modified "2023-09-26" @default.
• W2090871210 title "Regulation of collagenase gene expression by IL–1β requires transcriptional and post-transcriptional mechanisms" @default.
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• W2090871210 doi "https://doi.org/10.1093/nar/22.22.4818" @default.
• W2090871210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/308536" @default.
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