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- W2090872255 abstract "Peptide backbone modifications, involving either α-carbon changes or amide bond replacements, furnish new hybrid structures (pseudopeptides) with often profoundly altered physical and biological properties. Using both direct (ψ-condensation) and indirect (preformed pseudodipeptide) solid phase approaches, new cyclic enkephalin analogs have been prepared with a thiomethylene amide bond surrogate in the interior portion of the molecule. A drastic loss in potency observed with one of the analogs, when contrasted with the generally favorable utility of such replacements in small cyclic hosts, suggests a functional role for the 3–4 amide bond. The incorporation of three ψ[CH2S] replacements into an 18-Membered ring was effected in order to demonstrate the feasibility of synthesizing a new class of pseudopeptide (heterodetic) thioether macrocydes." @default.
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- W2090872255 date "1988-01-01" @default.
- W2090872255 modified "2023-09-23" @default.
- W2090872255 title "Amide bond surrogates: pseudopeptides and macrocycles" @default.
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- W2090872255 doi "https://doi.org/10.1016/s0040-4020(01)86119-6" @default.
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