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• W2090872774 abstract "Signaling through Trk receptor tyrosine kinases can occur in the absence of neurotrophins through certain G-protein-coupled receptors (GPCRs). It has previously been suggested that GPCR-mediated Trk activation occurs on intracellular membranes and involves several second messengers, including Src family kinases and intracellular calcium. Here, we describe a novel role for the Src family kinase, Fyn, in regulating signaling events between GPCRs and Trk. We find that Fyn expression is sufficient to allow transactivation of Trk by adenosine and that Fyn and Trk are colocalized in a juxtanuclear membrane compartment. Adenosine activation of Fyn results in direct phosphorylation of Trk in vitro and follows a delayed time course that coincides with Trk activation. These results indicate that Fyn is activated by GPCR stimulation and is responsible for transactivation of Trk receptors on intracellular membranes." @default.
• W2090872774 created "2016-06-24" @default.
• W2090872774 creator A5040096063 @default.
• W2090872774 creator A5083842270 @default.
• W2090872774 date "2006-09-01" @default.
• W2090872774 modified "2023-10-14" @default.
• W2090872774 title "A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling" @default.
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• W2090872774 doi "https://doi.org/10.1016/j.mcn.2006.06.002" @default.
• W2090872774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16860569" @default.
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