Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090875715> ?p ?o ?g. }
- W2090875715 endingPage "409" @default.
- W2090875715 startingPage "400" @default.
- W2090875715 abstract "Abstract NeuN is a 46/48‐kD nuclear protein antigen used widely to identify postmitotic neurons in both research and diagnostics. It is expressed by neurons throughout the nervous system of a variety of species, including birds, rodents, and man (Mullen et al. [1992] Development 116:201–211). When we sought to use NeuN to follow the developmental progression of murine cerebellar interneurons, we observed that expression of this antigen in the cerebellum was restricted to granule neurons and a small population of cells present in the lower molecular layer of the adult cerebellum. In an attempt to identify these cells, we combined immunostaining for NeuN with a panel of cell type‐specific markers to unambiguously identify neurons that express NeuN in the adult and developing cerebellum. In contrast to postmitotic granule neurons, NeuN was not expressed by any other immunocytochemically identified cerebellar interneurons, which comprised basket and stellate cells, Golgi neurons, unipolar brush cells, and Lugaro cells. NeuN‐positive cells in the molecular layer failed to express any cell type‐specific markers tested. They may represent ectopic granule cells; alternatively, they may represent a hitherto unknown population of cerebellar cells. In vitro experiments suggest that NeuN expression is related closely to granule cell axogenesis. This approach also revealed that the level of NeuN expression could be modulated by chronically depolarizing these cells. Thus, whereas NeuN expression per se is a reliable marker of proliferative capacity, levels of NeuN expression may also be indicative of the physiological status of a postmitotic neuron. © 2003 Wiley‐Liss, Inc." @default.
- W2090875715 created "2016-06-24" @default.
- W2090875715 creator A5016484047 @default.
- W2090875715 creator A5064545236 @default.
- W2090875715 date "2003-05-23" @default.
- W2090875715 modified "2023-10-15" @default.
- W2090875715 title "Developmental and cell type-specific expression of the neuronal marker NeuN in the murine cerebellum" @default.
- W2090875715 cites W1504992746 @default.
- W2090875715 cites W1572972152 @default.
- W2090875715 cites W1625542999 @default.
- W2090875715 cites W1942961343 @default.
- W2090875715 cites W1969724987 @default.
- W2090875715 cites W1972538107 @default.
- W2090875715 cites W1974551080 @default.
- W2090875715 cites W1987514728 @default.
- W2090875715 cites W1994030229 @default.
- W2090875715 cites W2001056945 @default.
- W2090875715 cites W2003410549 @default.
- W2090875715 cites W2023434269 @default.
- W2090875715 cites W2035427699 @default.
- W2090875715 cites W2038402478 @default.
- W2090875715 cites W2043500082 @default.
- W2090875715 cites W2057067798 @default.
- W2090875715 cites W2059407824 @default.
- W2090875715 cites W2060983457 @default.
- W2090875715 cites W2065968328 @default.
- W2090875715 cites W2066136635 @default.
- W2090875715 cites W2067270063 @default.
- W2090875715 cites W2071230078 @default.
- W2090875715 cites W2071263138 @default.
- W2090875715 cites W2072015526 @default.
- W2090875715 cites W2078319476 @default.
- W2090875715 cites W2088919410 @default.
- W2090875715 cites W2092910281 @default.
- W2090875715 cites W2104141601 @default.
- W2090875715 cites W2130118447 @default.
- W2090875715 cites W2140258821 @default.
- W2090875715 cites W2144698691 @default.
- W2090875715 cites W2158496649 @default.
- W2090875715 cites W2164167794 @default.
- W2090875715 cites W2166491434 @default.
- W2090875715 cites W2181633782 @default.
- W2090875715 cites W2427910088 @default.
- W2090875715 cites W4240738439 @default.
- W2090875715 cites W4296577018 @default.
- W2090875715 cites W4317524245 @default.
- W2090875715 doi "https://doi.org/10.1002/jnr.10655" @default.
- W2090875715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12868073" @default.
- W2090875715 hasPublicationYear "2003" @default.
- W2090875715 type Work @default.
- W2090875715 sameAs 2090875715 @default.
- W2090875715 citedByCount "231" @default.
- W2090875715 countsByYear W20908757152012 @default.
- W2090875715 countsByYear W20908757152013 @default.
- W2090875715 countsByYear W20908757152014 @default.
- W2090875715 countsByYear W20908757152015 @default.
- W2090875715 countsByYear W20908757152016 @default.
- W2090875715 countsByYear W20908757152017 @default.
- W2090875715 countsByYear W20908757152018 @default.
- W2090875715 countsByYear W20908757152019 @default.
- W2090875715 countsByYear W20908757152020 @default.
- W2090875715 countsByYear W20908757152021 @default.
- W2090875715 countsByYear W20908757152022 @default.
- W2090875715 countsByYear W20908757152023 @default.
- W2090875715 crossrefType "journal-article" @default.
- W2090875715 hasAuthorship W2090875715A5016484047 @default.
- W2090875715 hasAuthorship W2090875715A5064545236 @default.
- W2090875715 hasConcept C1491633281 @default.
- W2090875715 hasConcept C169760540 @default.
- W2090875715 hasConcept C189014844 @default.
- W2090875715 hasConcept C203014093 @default.
- W2090875715 hasConcept C204232928 @default.
- W2090875715 hasConcept C2776464000 @default.
- W2090875715 hasConcept C2778888523 @default.
- W2090875715 hasConcept C2779652256 @default.
- W2090875715 hasConcept C2781100881 @default.
- W2090875715 hasConcept C2908647359 @default.
- W2090875715 hasConcept C529278444 @default.
- W2090875715 hasConcept C54355233 @default.
- W2090875715 hasConcept C71924100 @default.
- W2090875715 hasConcept C86803240 @default.
- W2090875715 hasConcept C95444343 @default.
- W2090875715 hasConcept C99454951 @default.
- W2090875715 hasConceptScore W2090875715C1491633281 @default.
- W2090875715 hasConceptScore W2090875715C169760540 @default.
- W2090875715 hasConceptScore W2090875715C189014844 @default.
- W2090875715 hasConceptScore W2090875715C203014093 @default.
- W2090875715 hasConceptScore W2090875715C204232928 @default.
- W2090875715 hasConceptScore W2090875715C2776464000 @default.
- W2090875715 hasConceptScore W2090875715C2778888523 @default.
- W2090875715 hasConceptScore W2090875715C2779652256 @default.
- W2090875715 hasConceptScore W2090875715C2781100881 @default.
- W2090875715 hasConceptScore W2090875715C2908647359 @default.
- W2090875715 hasConceptScore W2090875715C529278444 @default.
- W2090875715 hasConceptScore W2090875715C54355233 @default.
- W2090875715 hasConceptScore W2090875715C71924100 @default.
- W2090875715 hasConceptScore W2090875715C86803240 @default.
- W2090875715 hasConceptScore W2090875715C95444343 @default.