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- W2090897823 abstract "Stimulation of secretory cells with muscarinic agonists leads to an increase in the intracellular Ca (2+)concentration ([Ca (2+)]( i)), which activates protein secretion through exocytosis and causes closure of gap junctions between adjacent cells. In addition, the increase in [Ca (2+)](i) activates three different kinds of ion channels: large K(+) channels, Cl(-) channels and non-specific cation channels. The opening of those channels leads to an increase of [Na(+ )] and a decrease of [Cl(-)] and [K(+) ] in the cell. The two components that contribute to the increase in [Ca (2+)]( i) are calcium release from intracellular stores, localised in the endoplasmic reticulum and calcium influx through the plasma membrane. Several models for the regulation of [Ca (2+)](i) have been proposed, including a recently suggested model whereby a distinct pathway involving arachidonic acid is added to the well-established capacitative model. Different hypotheses concerning coupling between the intra-cellular calcium stores and membrane channels co-exist. In addition to a historical overview, recent developments and future challenges are discussed in this review." @default.
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- W2090897823 date "2000-01-01" @default.
- W2090897823 modified "2023-09-26" @default.
- W2090897823 title "Calcium Signalling in Secretory Cells" @default.
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- W2090897823 doi "https://doi.org/10.1076/apab.108.5.385.4292" @default.
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