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- W2090897867 abstract "The ROS-GC subfamily of membrane guanylate cyclases is at present represented by two members: ROS-GC1 and ROS-GC2. A unique functional feature of this subfamily is that it is intracellularly modulated in low Ca2+ concentration by calmodulin-like Ca(2+)-binding proteins termed GCAPs, 1 and 2, and the modulation is consistent with its linkage to phototransduction. The present study shows that: (1) GCAP2 is a specific modulator of ROS-GC2; (2) through systematic remodeling of ROS-GC modules, the study also shows that the modulated domain resides within the amino acid segment 736-1020. This domain is distinct form the corresponding GCAP1-modulated ROS-GC1 domain. Thus, GCAP1 and GCAP2 act through different ROS-GCs and through two different cyclase domains." @default.
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- W2090897867 date "1998-04-01" @default.
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- W2090897867 title "Calcium Modulated Signaling Site in Type 2 Rod Outer Segment Membrane Guanylate Cyclase (ROS-GC2)" @default.
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- W2090897867 doi "https://doi.org/10.1006/bbrc.1998.8455" @default.
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