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- W2090901462 abstract "Objectives: Aggressive invasion and early metastases are characteristic features of pancreatic ductal adenocarcinoma (PDAC). More than 90% of patients have surgically nonresectable disease at presentation. Despite increasing knowledge of the genetics of this complex disease, systemic therapies, particularly gemcitabine, have modest clinical benefit and marginal survival advantage. MicroRNAs have been shown to have a role in oncogenesis, invasion, and metastases via epigenetic posttranscriptional gene regulation. Our objective was to discuss the clinical impact of microRNAs within PDAC. Methods: This review details the understanding of microRNAs to date and explores the clinical utility of microRNAs in PDAC. Results: Recent studies have focused on the impact of microRNA expression in PDAC, many of which have shown the diagnostic, predictive, and prognostic utility of microRNA profiling in PDAC identifying numerous potential targets including miR-21, miR-196a, and miR-217. Conclusions: MicroRNA stability in body fluid and tissue samples makes this area one of the most promising for earlier detection of PDAC. Indeed, microRNAs may in the future serve as a long-awaited screening tool for PDAC. Furthermore, microRNA expression profiling in PDAC may be incorporated into modern treatment algorithms to enhance therapeutic management. Equally as exciting is the potential for novel therapeutics directed against these important disease mediators." @default.
- W2090901462 created "2016-06-24" @default.
- W2090901462 creator A5070414319 @default.
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- W2090901462 date "2011-11-01" @default.
- W2090901462 modified "2023-10-07" @default.
- W2090901462 title "Clinical Potential of MicroRNAs in Pancreatic Ductal Adenocarcinoma" @default.
- W2090901462 cites W1976324983 @default.
- W2090901462 cites W1979673666 @default.
- W2090901462 cites W1980244442 @default.
- W2090901462 cites W1981889510 @default.
- W2090901462 cites W1985563073 @default.
- W2090901462 cites W1986110037 @default.
- W2090901462 cites W1989199090 @default.
- W2090901462 cites W1990645475 @default.
- W2090901462 cites W1999360191 @default.
- W2090901462 cites W2000093333 @default.
- W2090901462 cites W2002995168 @default.
- W2090901462 cites W2008945738 @default.
- W2090901462 cites W2011550114 @default.
- W2090901462 cites W2014442719 @default.
- W2090901462 cites W2014783179 @default.
- W2090901462 cites W2017905687 @default.
- W2090901462 cites W2020080445 @default.
- W2090901462 cites W2025449301 @default.
- W2090901462 cites W2025899661 @default.
- W2090901462 cites W2026468262 @default.
- W2090901462 cites W2035213975 @default.
- W2090901462 cites W2035987476 @default.
- W2090901462 cites W2049772720 @default.
- W2090901462 cites W2051227958 @default.
- W2090901462 cites W2052783034 @default.
- W2090901462 cites W2056494524 @default.
- W2090901462 cites W2059382687 @default.
- W2090901462 cites W2062290101 @default.
- W2090901462 cites W2066510471 @default.
- W2090901462 cites W2066868410 @default.
- W2090901462 cites W2075329854 @default.
- W2090901462 cites W2077547606 @default.
- W2090901462 cites W2078685029 @default.
- W2090901462 cites W2079251691 @default.
- W2090901462 cites W2085454747 @default.
- W2090901462 cites W2092018614 @default.
- W2090901462 cites W2098653030 @default.
- W2090901462 cites W2104610341 @default.
- W2090901462 cites W2108104027 @default.
- W2090901462 cites W2112087504 @default.
- W2090901462 cites W2112417639 @default.
- W2090901462 cites W2112785261 @default.
- W2090901462 cites W2115093090 @default.
- W2090901462 cites W2117391818 @default.
- W2090901462 cites W2120294133 @default.
- W2090901462 cites W2123962115 @default.
- W2090901462 cites W2124488916 @default.
- W2090901462 cites W2124603636 @default.
- W2090901462 cites W2125523949 @default.
- W2090901462 cites W2128562119 @default.
- W2090901462 cites W2129197203 @default.
- W2090901462 cites W2130979840 @default.
- W2090901462 cites W2132799739 @default.
- W2090901462 cites W2135074606 @default.
- W2090901462 cites W2135314242 @default.
- W2090901462 cites W2135613885 @default.
- W2090901462 cites W2135810600 @default.
- W2090901462 cites W2135836598 @default.
- W2090901462 cites W2142636026 @default.
- W2090901462 cites W2142801414 @default.
- W2090901462 cites W2144038313 @default.
- W2090901462 cites W2147807172 @default.
- W2090901462 cites W2150688669 @default.
- W2090901462 cites W2152036735 @default.
- W2090901462 cites W2154830487 @default.
- W2090901462 cites W2159833857 @default.
- W2090901462 cites W2161957137 @default.
- W2090901462 cites W2162224376 @default.
- W2090901462 cites W2163482204 @default.
- W2090901462 cites W2168829937 @default.
- W2090901462 cites W2910065277 @default.
- W2090901462 doi "https://doi.org/10.1097/mpa.0b013e3182218ffb" @default.
- W2090901462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22001830" @default.
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